Cdh13andAdipoQgene knockout alter instrumental and Pavlovian drug conditioning
| Autor: | J. Catlin, Paul J. Meyer, Jerry B. Richards, Abraham A. Palmer, C. L. St. Pierre, Emily Leung, Cassandra L. Versaggi, L. Militello, N. Roberson, Christopher P. King, Amy B. Hart |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Amphetamine-Related Disorders Conditioning Classical ADIPOQ Gene Pharmacology Choice Behavior Article Cocaine-Related Disorders 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Reward Reaction Time Genetics medicine Animals Attention deficit hyperactivity disorder Amphetamine Saccharin Rats Inbred Dahl Adiponectin Methamphetamine Cadherins medicine.disease Conditioned place preference Rats Associative learning 030104 developmental biology Neurology chemistry Conditioning Operant Female Cues Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Genes, Brain and Behavior. 16:686-698 |
| ISSN: | 1601-1848 |
| Popis: | Genome-wide association studies in humans have suggested that variants of the cadherin-13 (CDH13) gene are associated with substance use disorder, subjective response to amphetamine, and attention deficit hyperactivity disorder. To examine the role of the Cdh13 and its peptide ligand adiponectin (AdipoQ) in addiction-related behaviors, we assessed Cdh13 knock-out rats and AdipoQ knock-out mice using intravenous cocaine self-administration and conditioned place preference paradigms. During intravenous cocaine self-administration, male Cdh13 heterozygous (+/−) and knock-out (−/−) rats showed increased cue-induced reinstatement compared to wild-type rats when presented with a cocaine-paired stimulus, whereas female Cdh13 rats showed no differences across genotype. Cdh13 −/− rats showed higher responding for a saccharin reinforcer and learned the choice reaction time task more slowly than wild-types. However, we found no differences between Cdh13 −/− and +/+ rats in responding for sensory reinforcement, number of premature responses in the reaction time task, tendency to approach a Pavlovian food cue, conditioned place preference and locomotor activation to cocaine (10 or 20 mg/kg). In AdipoQ −/− mice there was a significant increase in conditioned place preference to methamphetamine (1 mg/kg) but not to a range of d-amphetamine doses (0.5, 1, 2 and 4 mg/kg). Taken together, these data suggest that Cdh13 and AdipoQ regulate sensitivity to psychomotor stimulants and palatable rewards without producing major changes in other behaviors. In humans, these two genes may regulate sensitivity to natural and drug rewards, thus influencing susceptibility to the conditioned drug effects and relapse. |
| Databáze: | OpenAIRE |
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