Heritability of plasma neopterin levels in the Old Order Amish
| Autor: | Mary Pavlovich, Lisa A. Brenner, Maureen Groer, John W. Stiller, Andrew J. Hoisington, Jeffrey R. O'Connell, Uttam K. Raheja, Cecile Punzalan, Hira Mohyuddin, Hassaan Yousufi, Sarah H. Stephens, Christopher A. Lowry, Toni I. Pollin, Teodor T. Postolache, Alan R. Shuldiner, Gursharon Nijjar, Dietmar Fuchs, Kathleen A. Ryan, Braxton D. Mitchell |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Gerontology Adult Male Aging Immunology Environment Neopterin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine immune system diseases Immunology and Allergy Medicine Humans Retrospective Studies business.industry Heritability Middle Aged humanities 030104 developmental biology Neurology chemistry Old Order Amish Biomarker (medicine) Female Neurology (clinical) business Amish 030217 neurology & neurosurgery Demography |
| Zdroj: | Journal of neuroimmunology. 307 |
| ISSN: | 1872-8421 |
| Popis: | Background We examined the heritability of neopterin, a biomarker for cell-mediated immunity and oxidative stress, and potentially for psychiatric disorders, in the Old Order Amish. Methods Plasma neopterin levels were determined in 2015 Old Order Amish adults. Quantitative genetic procedures were used to estimate heritability of neopterin. Results Heritability of log-neopterin was estimated at 0.07 after adjusting for age, gender, and household ( p = 0.03). The shared household effect was 0.06 ( p Conclusions We found a low heritability of neopterin and small household effect, suggesting that non-household environmental factors are more important determinants of variance of neopterin levels in the Amish. |
| Databáze: | OpenAIRE |
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