Photothermally triggered on-demand insulin release from reduced graphene oxide modified hydrogels

Autor: Rana Sanyal, Amitav Sanyal, Marie Lecoeur, Gurvan Queniat, Amar Abderrahmani, Yavuz Oz, Florina Teodorescu, Sabine Szunerits, Catherine Foulon, Rabah Boukherroub
Přispěvatelé: Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Boǧaziçi üniversitesi = Boğaziçi University [Istanbul], Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), European Project: 690836,H2020,H2020-MSCA-RISE-2015,PANG(2016), Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (GI3M), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Boğaziçi University [Istanbul], Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2017
Předmět:
Hot Temperature
Light
Swine
Skin Absorption
medicine.medical_treatment
Oxide
Pharmaceutical Science
Nanotechnology
02 engineering and technology
Administration
Cutaneous
010402 general chemistry
01 natural sciences
Hydrogel
Polyethylene Glycol Dimethacrylate
Polyethylene Glycols
law.invention
chemistry.chemical_compound
law
On demand
medicine
Animals
Humans
Hypoglycemic Agents
Insulin
Triggered release
chemistry.chemical_classification
Graphene
Biomolecule
technology
industry
and agriculture
Hep G2 Cells
021001 nanoscience & nanotechnology
0104 chemical sciences
[CHIM.POLY]Chemical Sciences/Polymers
[SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology
chemistry
Delayed-Action Preparations
Self-healing hydrogels
Methacrylates
Graphite
Caco-2 Cells
0210 nano-technology
Oxidation-Reduction
Ethylene glycol
Zdroj: Journal of Controlled Release
Journal of Controlled Release, 2017, 246, pp.164-173. ⟨10.1016/j.jconrel.2016.10.028⟩
Journal of Controlled Release, Elsevier, 2017, 246, pp.164-173. ⟨10.1016/j.jconrel.2016.10.028⟩
ISSN: 0168-3659
Popis: International audience; On-demand delivery of therapeutics plays an essential role in simplifying and improving patient care. The high loading capacity of reduced graphene oxide (rGO) for drugs has made this matrix of particular interest for its hybridization with therapeutics. In this work, we describe the formulation of rGO impregnated poly(ethylene glycol) dimethacrylate based hydrogels (PEGDMA-rGO) and their efficient loading with insulin. Near-infrared (NIR) light induced heating of the PEGDMA-rGO hydrogels allows for highly efficient insulin release. Most importantly, we validate that the NIR irradiation of the hydrogel has no effect on the biological and metabolic activities of the released insulin. The ease of insulin loading/reloading makes this photothermally triggered release strategy of interest for diabetic patients. Additionally, the rGO-based protein releasing platform fabricated here can be expanded towards 'on demand' release of various other therapeutically relevant biomolecules. Graphical abstract. The table of contents entry: Poly(ethylene glycol) based hydrogels impregnated with rGO allow efficient loading and 'on demand' photothermal release of insulin while preserving its biological and metabolic activity.
Databáze: OpenAIRE
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