Emerging diagnostic tests for vitreoretinal lymphoma: a review
| Autor: | Binoy Appukuttan, Abby C. Dawson, Keryn A. Williams, Justine R. Smith |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Retinal Neoplasm
Retinal Neoplasms Immunoglobulins Bioinformatics Retina law.invention 03 medical and health sciences 0302 clinical medicine law hemic and lymphatic diseases Biomarkers Tumor Humans Medicine Genetic Testing RNA Neoplasm Polymerase chain reaction Genetic testing Gene Rearrangement biology medicine.diagnostic_test business.industry Cancer Gene rearrangement medicine.disease 3. Good health Lymphoma Vitreous Body Ophthalmology 030220 oncology & carcinogenesis Mutation 030221 ophthalmology & optometry biology.protein Cytokines Lymphoma Large B-Cell Diffuse Antibody business Vitreoretinal lymphoma |
| Zdroj: | Clinical & Experimental Ophthalmology. 46:945-954 |
| ISSN: | 1442-9071 1442-6404 |
| DOI: | 10.1111/ceo.13304 |
| Popis: | Vitreoretinal lymphoma, which most commonly is diffuse large B-cell non-Hodgkin in type, is a rare cancer with high morbidity and high mortality. Making a tissue diagnosis of vitreoretinal lymphoma is a major challenge for clinicians due to biological and technical factors. Yet, the delay in start of treatment may have vision- and life-threatening consequences, and there is considerable interest in the application of molecular assays to improve the accuracy of the diagnostic process: detection of a clonal immunoglobulin heavy-chain rearrangements in lymphoma cells by polymerase chain reaction; measurement of vitreous or aqueous interleukin-10 protein levels in ocular fluids; and identification of mutations in the myeloid differentiation primary response gene 88 in tumour cells. In this article, we review the historical development and current application of each of these molecular methods. We also discuss future opportunities for the molecular diagnosis of vitreoretinal lymphoma through next-generation sequencing technologies. |
| Databáze: | OpenAIRE |
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