A Pilot Investigation of Repetitive Transcranial Magnetic Stimulation for Post-Traumatic Brain Injury Depression: Safety, Tolerability, and Efficacy
| Autor: | David Elliot, Susan McQueen, Sally E. Herring, Paul B. Fitzgerald, Kate E. Hoy, Jerome Joseph Maller |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 030506 rehabilitation medicine.medical_specialty Traumatic brain injury medicine.medical_treatment Pilot Projects Transcranial Direct Current Stimulation 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Double-Blind Method Brain Injuries Traumatic medicine Humans Depression (differential diagnoses) Aged Depression business.industry Safety tolerability Middle Aged medicine.disease Clinical trial Transcranial magnetic stimulation Treatment Outcome Female Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma. 36:2092-2098 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2018.6097 |
| Popis: | Depression following a traumatic brain injury (TBI) is common and difficult to treat using standard approaches. The current study investigated, for the first time, transcranial magnetic stimulation (TMS) for the treatment of post TBI depression. We specifically assessed the safety, tolerability, and efficacy of TMS in this patient population. We also explored cognitive outcomes. Twenty-one patients with a current episode of major depression subsequent to a TBI participated in a randomized double-blind placebo-controlled trial of repetitive TMS (rTMS). Sequential bilateral rTMS (to the left and right dorsolateral prefrontal cortex) was provided in 20 treatments over a period of 4 weeks. Patients were randomly allocated to receive either active or sham stimulation. There were no adverse effects and treatment was well tolerated. There was no significant effect of rTMS on post-TBI depression, with all patients showing a significant improvement in depressive symptoms irrespective of their treatment group ( |
| Databáze: | OpenAIRE |
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