Codeine and aspirin analgesia in postpartum uterine cramps: qualitative aspects of quantitative assessments
| Autor: | Jeanette Mitchell, Tom P. Barden, Saul S. Bloomfield, Gail Cissell |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Episiotomy
Adult Adolescent medicine.medical_treatment Analgesic Pain Placebo law.invention Random Allocation Randomized controlled trial Double-Blind Method law Oral administration Pregnancy Medicine Humans Pharmacology (medical) Pharmacology Aspirin Analgesics business.industry Codeine Postpartum Period Concomitant Anesthesia Drug Evaluation Female business medicine.drug |
| Zdroj: | Clinical pharmacology and therapeutics. 34(4) |
| ISSN: | 0009-9236 |
| Popis: | The analgesic response to codeine of patients with postpartum uterine-cramp pain has recently met with controversy. To readdress this question, we conducted a new study comparing codeine sulfate, 60 mg (N = 32) and 120 mg (N = 31), with aspirin, 650 mg (N = 34), and placebo (N = 32) in hospitalized women with moderate or severe postpartum uterine cramps treated with single oral doses in a parallel, stratified, randomized, double-blind trial. Subjective reports were used as indices of response, and patients rated pain intensity, pain relief, and side effects at periodic, uniformly conducted interviews for 6 hr. Most measures of analgesia exhibited important differences among the treatments. In patients with undifferentiated pain (N = 129) and in a subset of patients with pure uterine cramps (N = 56; i.e., no concomitant episiotomy), aspirin showed the greatest response, whereas codeine responses were equivocal with no evidence of a positive dose response. In contrast, in a subset of patients with mixed episiotomy-uterine pain (N = 73), 120 mg codeine showed good separation from placebo and compared favorably with aspirin. Codeine, 60 mg, showed a similar trend, and there was a strong suggestion of dose-dependent analgesia. Side effects were not remarkable except for dizziness and drowsiness after 120 mg codeine in all sets and subsets of patients.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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