ADRENAL ORIGIN OF PLASMA CATECHOLAMINES AFTER DECAPITATION: A STUDY IN NORMAL AND DIABETIC RATS
| Autor: | Barry A. Berkowitz, R.J. Head |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Pharmacology
medicine.medical_specialty Sympathetic nervous system Time Factors business.industry Dopamine beta-monooxygenase Dopamine beta-Hydroxylase medicine.disease Diabetes Mellitus Experimental Rats Catecholamines Endocrinology medicine.anatomical_structure Internal medicine Diabetes mellitus Adrenal Glands medicine Animals High activity business Research Article |
| Zdroj: | British Journal of Pharmacology. 64:3-5 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1978.tb08632.x |
| Popis: | The concentrations of catecholamines and the activities of dopamine-beta-hydroxylase were measured in blood obtained from decapitated diabetic and aged-matched control rats. The activity of dopamine-beta-hydroxylase in blood from diabetic rats was much greater (5 fold) than that seen for control rats. For both diabetic and control rats, decapitation was accompanied by an increase in levels of adrenaline and noradrenaline with no change in the activity of plasma dopamine-beta-hydroxylase. The results are consistent with a predominantly adrenal origin of catecholamines and extra-adrenal origin of dopamine-beta-hydroxylase. The high activity of dopamine-beta-hydroxylase in diabetes indicates either an increased activity of the sympathetic nervous system or changes in dopamine-beta-hydroxylase turnover. |
| Databáze: | OpenAIRE |
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