Anticholinesterase activity of organophosphate nerve agents in neuronal tissue culture

Autor:	R.J. Unger, T.W. Sawyer, M.T. Weiss
Rok vydání:	1991
Předmět:	animal structures Aché Chemistry Organophosphate General Medicine Pharmacology Toxicology In ovo Acetylcholinesterase language.human_language chemistry.chemical_compound Tissue culture Biochemistry In vivo Soman language medicine Nerve agent medicine.drug
Zdroj:	Toxicology in vitro : an international journal published in association with BIBRA. 6(3)
ISSN:	0887-2333
Popis:	Primary chick embryo forebrain culture was examined with respect to its usefulness as a model to study organophosphate (OP) anticholinesterases. The acetylcholinesterase (AChE) activity of these cultures increased with time in culture and paralleled the development in ovo of this enzyme. The neuronal cells were extremely sensitive to the anticholinesterase effects of OP nerve agents, and experiments with soman indicated that enzyme inhibition was rapid and persistent. The potencies of several OP nerve agents as inhibitors of AChE activity in vitro paralleled their literature-reported toxicities in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c3913d9d413c3754c460e4085b19a6 https://pubmed.ncbi.nlm.nih.gov/20732122 Zobrazit plný text záznamu