Chronic exposure to a pollutant mixture at low doses led to tissue-specific metabolic alterations in male mice fed standard and high-fat high-sucrose diet

Autor: Hubert Vidal, Nathalie Vega, Brigitte Le Magueresse-Battistoni, Baptiste Julien, Guillain Gaillard, Stéphanie Chanon, Danielle Naville, Claudie Pinteur
Přispěvatelé: Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA), Institut National de la Recherche Agronomique (INRA), Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM, University Lyon1, French 'Ministere de I'Education Nationale, de l'Enseignement Supérieur et de la Recherche, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), French 'Ministere de I'Education Nationale, de l'Enseignement Supérieur et de la RechercheUniversity of Lyon1 French 'Ministere de I'Education Nationale, de l'Enseignement Superieur et de la Recherche'
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
high-fat high-sucrose diet
obesity
metabolic disturbances
Health
Toxicology and Mutagenesis
0208 environmental biotechnology
Adipose tissue
tissu adipeux
sugar (sucrose)
02 engineering and technology
010501 environmental sciences
souris
01 natural sciences
Jejunum
chemistry.chemical_compound
profil d'expression
Tissue Distribution
2. Zero hunger
Lipoprotein lipase
sucrose
General Medicine
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Pollution
3. Good health
adipose tissue
obésité
medicine.anatomical_structure
endocrine disruptors
Adipogenesis
cocktail effect
Environmental Pollutants
pollutant
medicine.medical_specialty
Environmental Engineering
mice
[SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain
Biology
Diet
High-Fat
Insulin resistance
Internal medicine
medicine
Animals
Environmental Chemistry
distribution tissulaire
jejunum
0105 earth and related environmental sciences
Gene Expression Profiling
polluant
Public Health
Environmental and Occupational Health
Environmental Exposure
General Chemistry
Metabolism
medicine.disease
Obesity
mixture of pollutants
020801 environmental engineering
Endocrinology
chemistry
13. Climate action
[SDE.BE]Environmental Sciences/Biodiversity and Ecology
Xenobiotic
Zdroj: Chemosphere
Chemosphere, Elsevier, 2019, 220, pp.1187-1199. ⟨10.1016/j.chemosphere.2018.12.177⟩
Chemosphere, Elsevier, 2019, 220, pp.1187-1199
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2018.12.177⟩
Popis: International audience; Excessive consumption of industrialized food and beverages is a major etiologic factor in the epidemics of obesity and associated metabolic diseases because these products are rich in fat and sugar. In addition, they contain food contact materials and environmental pollutants identified as metabolism disrupting chemicals. To evaluate the metabolic impact of these dietary threats (individually or combined), we used a male mouse model of chronic exposure to a mixture of low-dose archetypal food-contaminating chemicals that was added in standard or high-fat, high-sucrose (HFHS) diet. Specifically, the mixture contained bisphenol A, diethylhexylphthalate, 2,3,7,8-tetrachlorodibenzo-p-dioxine and polychlorinated biphenyl 153. Exposure lasted from 5 to 20 weeks of age. Metabolic exploration was conducted setting the basis of candidate gene expression mRNA analyses in liver, jejunum and adipose tissue depots from 20 week-old mice. Strong metabolic deleterious effects of the HFHS diet were demonstrated in line with obesity-associated metabolic features and insulin resistance. Pollutant exposure resulted in significant changes on plasma triglyceride levels and on the expression levels of genes mainly encoding xenobiotic processing in jejunum; estrogen receptors, regulators of lipoprotein lipase and inflammatory markers in jejunum and adipose tissues as well as adipogenesis markers. Importantly, the impact of pollutants was principally evidenced under standard diet. In addition, depending on nutritional conditions and on the metabolic tissue considered, the impact of pollutants could mimic or oppose the HFHS effects. Collectively, the present study extends the cocktail effect concept of a low-dosed pollutant mixture and originally points to tissue-specificity responsiveness especially in jejunum and adipose tissues.
Databáze: OpenAIRE
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