Coxiella burnetii (Q fever) prevalence in associated populations of humans and small ruminants in The Gambia

Autor: Bok, Jeroen, Hogerwerf, Lenny, Germeraad, Eveline A., Roest, Hendrik I J, Faye-Joof, Tisbeh, Jeng, Momodou, Nwakanma, Davis, Secka, Arss, Stegeman, Arjan, Goossens, Bart, Wegm??ller, Rita, van der Sande, Marianne A B, van der Hoek, Wim, Secka, Ousman, LS Evidence Based Vet Medicine, Dep Infectieziekten Immunologie, LS GZ Landbouwhuisdieren, dFAH I&I, dFAH AVR
Přispěvatelé: LS Evidence Based Vet Medicine, Dep Infectieziekten Immunologie, LS GZ Landbouwhuisdieren, dFAH I&I, dFAH AVR
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Veterinary medicine
Endemic Diseases
Epidemiology
Prevalence
seroepidemiologic studies
0302 clinical medicine
Risk Factors
Zoonoses
Odds Ratio
030212 general & internal medicine
Animal Husbandry
humans
Aged
80 and over
Bacterial Shedding
biology
Middle Aged
Infectious Diseases
Coxiella burnetii
Female
Gambia
Public Health
Adult
sheep
goats
Adolescent
Bioinformatica & Diermodellen
030231 tropical medicine
Q fever
Antibodies
03 medical and health sciences
Young Adult
Bio-informatics & Animal models
medicine
Journal Article
Seroprevalence
Animals
Epidemiology
Bio-informatics & Animal models
Risk factor
Aged
Epidemiologie
Environmental and Occupational Health
Public Health
Environmental and Occupational Health
Odds ratio
Seroepidemiologic Studies
biology.organism_classification
medicine.disease
bacterial infections and mycoses
Virology
Parasitology
Epidemiologie
Bioinformatica & Diermodellen
bacteria
Zdroj: Tropical Medicine and International Health 22 (2017) 3
Tropical medicine & international health, 22(3), 323. Wiley-Blackwell
Tropical Medicine and International Health, 22(3), 323. Blackwell Publishing Ltd
Tropical Medicine and International Health, 22(3), 323-331
ISSN: 1360-2276
Popis: Objectives: To simultaneously estimate the prevalence of antibodies against Coxiella burnetii (Q fever) among adults and small ruminants, and C. burnetii shedding prevalence among small ruminants in households in the Kiang West district of The Gambia, and to assess associated risk factors. Methods: Sera of 599 adults and 615 small ruminants from 125 compounds within 12 villages were tested for antibodies against C. burnetii using ELISA. Vaginal swabs and milk samples of 155 small ruminants were tested using PCR to investigate shedding of C. burnetii. Results: A total of 3.8–9.7% of adults, depending on ELISA test cut-off, and 24.9% of small ruminants in Kiang West were seropositive. Having at least one seropositive animal in one's compound was a risk factor for human seropositivity (OR: 3.35, 95% CI: 1.09–14.44). A grazing area within a village was a risk factor for seropositivity in small ruminants (OR: 2.07, 95% CI: 1.26–3.50); others were having lambed (OR: 2.75, 95% CI: 1.37–5.76) and older age of the animals (OR: 2.75, 95% CI: 1.37–5.76 for 1–3 years and OR 5.84, 95% CI: 3.10–11.64 for >3 years); 57.4% of sampled small ruminants were shedding C. burnetii. Conclusion: Coxiella burnetii infection is endemic among both humans and small ruminants in this area of The Gambia. Human and animal exposure to C. burnetii were related at compound level. Further research into the clinical relevance of C. burnetii infection in West Africa is needed.
Databáze: OpenAIRE
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