Green Approach Extraction of Perezone from the Roots of Acourtia platyphilla (A. Grey): A Comparison of Four Activating Modes and Supercritical Carbon Dioxide
| Autor: | Julián Cruz-Olivares, René Escobedo-González, Andrea Vázquez Vázquez Cabañas, Juan Nava Serrano, René Miranda Ruvalcaba, Armando Martínez González, Joel Martínez, Pablo I. Mendoza Sánchez, Zenaida Saavedra-Leos |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pharmaceutical Science
Asteraceae 010402 general chemistry 01 natural sciences Plant Roots Article microwaves Analytical Chemistry lcsh:QD241-441 lcsh:Organic chemistry supercritical carbon dioxide Computational chemistry Drug Discovery green approach Molecule Acourtia Physical and Theoretical Chemistry Solubility perezone-sesquiterpene quinone Supercritical carbon dioxide biology 010405 organic chemistry Chemistry ultrasound Plant Extracts Organic Chemistry Extraction (chemistry) Chromatography Supercritical Fluid Carbon Dioxide biology.organism_classification Supercritical fluid 0104 chemical sciences Quinone comparative extraction Chemistry (miscellaneous) infrared Proton NMR Molecular Medicine Sesquiterpenes |
| Zdroj: | Molecules Molecules, Vol 24, Iss 17, p 3035 (2019) Volume 24 Issue 17 |
| ISSN: | 1420-3049 |
| Popis: | Perezone, a sesquiterpene quinone, is a very important molecule due to its pharmacological activities in addition to the fact that it is considered to be the first secondary metabolite isolated in the new world (America&ndash Mexico, 1852). This study aims to offer a green comparative study about the extraction of the target molecule from the roots of the vegetable specimen Acourtia platyphilla (A. Grey). The study was performed comparing five different modes of extraction: supercritical CO2, electromagnetic infrared and microwave irradiations, mechanical-wave ultrasound versus typical mantle heating procedure. An exhaustive comparative-discussion of the obtained results is provided. It is worth noting that the corresponding quantifications were established using 1H NMR, correlating appropriately the integrals of the vinylic proton H-6 of perezone with the aromatic singlet of p-dinitrobenzene employed as an internal reference. It is also important to highlight that the four presented procedures are novel modes to extract perezone. Finally, a complementary study about the solubility of the target sesquiterpene quinone related to the use of supercritical CO2 is also reported. |
| Databáze: | OpenAIRE |
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