Can low-dose CT perfusion imaging accurately assess response of advanced gastric cancer with neoadjuvant chemotherapy?
| Autor: | Zongqiong Sun, Linfang Jin, Peng Zhao, Jie Li, Yu-Xi Ge, Zhi-Hui Xie, Gen Yan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Urology Hemodynamics Blood volume Perfusion scanning Radiation Dosage Sensitivity and Specificity 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Electrical and Electronic Engineering Instrumentation Aged Chemotherapy Radiation Receiver operating characteristic business.industry Stomach Area under the curve Reproducibility of Results Blood flow Middle Aged Condensed Matter Physics Neoadjuvant Therapy stomatognathic diseases 030220 oncology & carcinogenesis Female Radiology Tomography X-Ray Computed business Perfusion |
| Zdroj: | Journal of X-Ray Science and Technology. 25:981-991 |
| ISSN: | 1095-9114 0895-3996 |
| Popis: | PURPOSE To explore the value of low-dose CT perfusion imaging (LDCTPI) technology and its perfusion parameters in assessing response of neoadjuvant chemotherapy (NAC) in patients with advanced gastric cancer (AGC). METHODS Thirty patients with AGC were studied prospectively by LDCTPI to measure two parameters including blood flow (BF) and blood volume (BV) of tumor area before and after chemotherapy, respectively. All of the patients received two courses of NAC and surgical resection of gastric tumor within one week after chemotherapy, and then obtained the result of postoperative pathology response for chemotherapy. The comparisons of BF and BV values of AGC before and after chemotherapy were analyzed by paired-samples t-test, respectively; and the correlations between BF as well as BV decrease rates after NAC and the pathology response grade were analyzed by Spearman statistical test. Thirty patients were divided into effective and ineffective groups according to different pathology response grade. Comparisons of BF as well as BV decrease rates between effective and ineffective groups were analyzed by independent-samples t-test, respectively. Receiver operating characteristic (ROC) curves were used to determine the cutoff values of BF and BV decrease rates as evaluation indicators of AGC after NAC and calculate area under the curve (AUC). RESULTS There were significant differences in BF and BV values of AGC between before and after NAC (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|