Elemental imaging of MRI contrast agents: benchmarking of LA-ICP-MS to MRI
| Autor: | Michele J. Writer, Jimmy D. Bell, Edward White, Cameron W. McLeod, Alan G. Cox, Josephine Bunch, John A. Pugh, Alison Bienemann, Stephen L. Hart |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Gadolinium DTPA
Elemental imaging Swine media_common.quotation_subject Contrast Media Biochemistry Carboplatin Analytical Chemistry chemistry.chemical_compound Nuclear magnetic resonance La icp ms In vivo medicine Animals Contrast (vision) Inductively coupled plasma mass spectrometry media_common medicine.diagnostic_test Chemistry Brain Magnetic resonance imaging Magnetic Resonance Imaging Rats Chemotherapy Drugs Liposomes Nanoparticles |
| Zdroj: | Analytical and Bioanalytical Chemistry. 403:1641-1649 |
| ISSN: | 1618-2650 1618-2642 |
| DOI: | 10.1007/s00216-012-5973-z |
| Popis: | Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been used to map the spatial distribution of magnetic resonance imaging (MRI) contrast agents (Gd-based) in histological sections in order to explore synergies with in vivo MRI. Images from respective techniques are presented for two separate studies namely (1) convection enhanced delivery of a Gd nanocomplex (developmental therapeutic) into rat brain and (2) convection enhanced delivery, with co-infusion of Magnevist (commercial Gd contrast agent) and Carboplatin (chemotherapy drug), into pig brain. The LA technique was shown to be a powerful compliment to MRI not only in offering improved sensitivity, spatial resolution and signal quantitation but also in giving added value regarding the fate of administered agents (Gd and Pt agents). Furthermore simultaneous measurement of Fe enabled assignment of an anomalous contrast enhancement region in rat brain to haemorrhage at the infusion site. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|