Role of calcineurin biosignaling in cell secretion and the possible regulatory mechanisms
| Autor: | Saeedah Hamdan Al-Jadani, Saad Saeed Alamri, Hani Alothaid, Jehan S. Alrahimi, Mohammed S. Aldughaim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Phosphatase Review 01 natural sciences 03 medical and health sciences chemistry.chemical_compound ROS reactive oxygen species Cell secretion CREB cAMP-responsive element-binding protein Cyclic adenosine monophosphate Secretion lcsh:QH301-705.5 Cn calcineurin Kinase PP protein phosphatase Protein phosphatase 2 RyR ryanodine receptor cAMP signaling PP2B Cell biology Calcineurin cAMP cyclic adenosine monophosphate Intercellular communication NFAT nuclear factor of activated T-cells 030104 developmental biology chemistry lcsh:Biology (General) Phosphorylation Protein kinases/phosphatases PKA protein kinase A General Agricultural and Biological Sciences Intracellular 010606 plant biology & botany |
| Zdroj: | Saudi Journal of Biological Sciences Saudi Journal of Biological Sciences, Vol 28, Iss 1, Pp 116-124 (2021) |
| ISSN: | 2213-7106 1319-562X |
| Popis: | Cyclic adenosine monophosphate (cAMP) and calcium ions (Ca2+) are two chemical molecules that play a central role in the stimulus-dependent secretion processes within cells. Ca2+ acts as the basal signaling molecule responsible to initiate cell secretion. cAMP primarily acts as an intracellular second messenger in a myriad of cellular processes by activating cAMP-dependent protein kinases through association with such kinases in order to mediate post-translational phosphorylation of those protein targets. Put succinctly, both Ca2+ and cAMP act by associating or activating other proteins to ensure successful secretion. Calcineurin is one such protein regulated by Ca2+; its action depends on the intracellular levels of Ca2+. Being a phosphatase, calcineurin dephosphorylate and other proteins, as is the case with most other phosphatases, such as protein phosphatase 2A (PP2A), PP2C, and protein phosphatase-1 (PP1), will likely be activated by phosphorylation. Via this process, calcineurin is able to affect different intracellular signaling with clinical importance, some of which has been the basis for development of different calcineurin inhibitors. In this review, the cAMP-dependent calcineurin bio-signaling, protein-protein interactions and their physiological implications as well as regulatory signaling within the context of cellular secretion are explored. |
| Databáze: | OpenAIRE |
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