Pembrolizumab as a novel therapeutic option for patients with refractory thymic epithelial tumor: A case report
| Autor: | Maureen Bernadach, Xavier Durando, Jonathan Wong-Chong, Angeline Ginzac, Hugo Veyssière |
|---|---|
| Přispěvatelé: | Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne (UCA), Veyssère, Hugo, Centre d'investigation Clinique, UMR501, 63011 CLERMONT-FERRAND (CIC) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
[SDV.CAN]Life Sciences [q-bio]/Cancer
Pembrolizumab [SDV.GEN] Life Sciences [q-bio]/Genetics Metastasis 03 medical and health sciences 0302 clinical medicine Refractory [SDV.CAN] Life Sciences [q-bio]/Cancer Case report Medicine ComputingMilieux_MISCELLANEOUS [SDV.GEN]Life Sciences [q-bio]/Genetics business.industry Thymic epithelial carcinoma Programmed death-ligand 1 negative General Medicine medicine.disease Immune checkpoint 3. Good health 030220 oncology & carcinogenesis Thymic epithelial tumor Cancer research 030211 gastroenterology & hepatology business |
| Zdroj: | World Journal of Clinical Cases World Journal of Clinical Cases, 2021, 9 (5), pp.1139-1147. ⟨10.12998/wjcc.v9.i5.1139⟩ World Journal of Clinical Cases, Baishideng Publishing Group 2021, 9 (5), pp.1139-1147. ⟨10.12998/wjcc.v9.i5.1139⟩ |
| ISSN: | 2307-8960 |
| DOI: | 10.12998/wjcc.v9.i5.1139⟩ |
| Popis: | BACKGROUND Thymic epithelial carcinomas are rare and have a poor prognosis. Treatment of thymic epithelial carcinoma is multimodal and includes surgery, post-operative radiation therapy, adjuvant and neoadjuvant chemotherapy, or exclusive chemotherapy based on disease resectability. However, there is currently no standard treatment regimen for metastatic and recurrent thymic carcinoma. CASE SUMMARY A 45-year-old Caucasian male, with no past medical history, presented with hepatalgia and a cervical mass. A computed tomography (CT) scan showed multiple suspect lesions in the lungs, liver, and anterior mediastinum associated with mediastinal and cervical adenopathy. CT-guided percutaneous biopsies of the liver lesions and anterior mediastinal mass were performed, confirming the histopathology of thymic epithelial carcinoma. Management consisted of several chemotherapy regimens and radiation therapy, administered between April 2016 and December 2018. The patient achieved complete metabolic response. Fluorodeoxyglucose positron emission tomography/CT performed in June 2019 showed disease relapse, with reappearance of a large hypermetabolic hepatic mass and involvement of mediastinal and axillary lymph nodes. Intravenous pembrolizumab (200 mg, every 3 wk) was administered after two prior systemic therapies. The patient’s response to treatment was last documented on March 5, 2020. CONCLUSION Pembrolizumab was successful in treatment of a patient with programmed death-ligand 1-negative metastatic thymic carcinoma, pretreated with chemotherapy. |
| Databáze: | OpenAIRE |
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