Nickel as a virulence factor in the Class I bacterial carcinogen, Helicobacter pylori
| Autor: | Michael J. Maroney, Stefano Ciurli |
|---|---|
| Přispěvatelé: | Maroney M.J., Ciurli S. |
| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
0301 basic medicine Cancer Research Hydrogenase Urease Virulence Factors Virulence Virulence factor Microbiology Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Nickel otorhinolaryngologic diseases Animals Humans Pathogen Carcinogen chemistry.chemical_classification biology Helicobacter pylori biology.organism_classification 030104 developmental biology Enzyme chemistry 030220 oncology & carcinogenesis biology.protein Carcinogens |
| Zdroj: | Seminars in cancer biology. 76 |
| ISSN: | 1096-3650 |
| Popis: | Helicobacter pylori is a human bacterial pathogen that causes peptic ulcers and has been designated a Class I carcinogen by the International Agency for Research on Cancer (IARC). Its ability to survive in the acid environment of the stomach, to colonize the stomach mucosa, and to cause cancer, are linked to two enzymes that require nickel—urease and hydrogenase. Thus, nickel is an important virulence factor and the proteins involved in nickel trafficking are potential antibiotic targets. This review summarizes the nickel biochemistry of H. pylori with a focus on the roles of nickel in virulence, nickel homeostasis, maturation of urease and hydrogenase, and the unique nickel trafficking that occurs between the hydrogenase maturation pathway and urease nickel incorporation that is mediated by the metallochaperone HypA and its partner, HypB. |
| Databáze: | OpenAIRE |
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