Reyes's syndrome, encephalopathy, hyperammonemia and acetyl salicylic acid ingestion in a city hospital of Buenos Aires, Argentina
| Autor: | Juan Carlos Perazzo, María Alejandra Fernández, Abraham Lemberg, Diego O. Rosello, Salvador Romay, Carlos Coll, Ester Julia Filinger |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Farmacología y Farmacia CIENCIAS MÉDICAS Y DE LA SALUD Encephalopathy Argentina Glutamic Acid Brain damage Hypoglycemia Toxicology Gastroenterology ACETYL SALICYLIC ACID REYE'S SYNDROME Internal medicine medicine Reye's syndrome Ingestion Humans Hyperammonemia Pharmacology (medical) Aspartate Aminotransferases Child Hyperbilirubinemia Retrospective Studies Pharmacology Aspirin business.industry Reye Syndrome Anti-Inflammatory Agents Non-Steroidal ENCEPHALOPATHY Alanine Transaminase medicine.disease Medicina Básica Mitochondrial permeability transition pore Anesthesia Astrocytes Child Preschool Female medicine.symptom business Mitochondrial Swelling HYPERAMMONEMIA medicine.drug |
| Zdroj: | Current drug safety. 4(1) |
| ISSN: | 1574-8863 |
| Popis: | Twelve cases of Reye's syndrome are presented with different degrees of encephalopathy, hyperammonemia and hypoglycemia; associated to acetyl salicylic acid (ASA) ingestion. The aim of the present retrospective study was to describe our experience in selected patients with Reye's syndrome associated to the ASA ingestion and to underline the influence of hyperammonemia on Reye's encephalopathy. All the cases presented moderate hyperbilirubinemia, elevated alanine aminotransferase, aspartate aminotransferase with an average of 302±205 UI/L and 285±149 UI/L respectively. Arterial blood ammonia averaged 172.4±71.3 μmol/L and glycaemia averaged 35.2±17.0 mg/ dl. A high mortality was found in our series (41.7%). Considering that encephalopathy is the leading syndrome in these cases, the influence of ammonia on brain tissue was described. Glutamate is an excitotoxic neurotransmitter, capable to produce neuron and astrocyte damage and apoptosis. The presence of ASA could cause the onset of the mitochondrial permeability transition and the mitochondrial swelling in the astrocyte, leading to hyperammonemia. In Reye's syndrome, hyperammonemia and perhaps the increase of glutamate are the leading factors in the mechanism of brain damage and encephalopathy. Aspirin must be carefully administrated and controlled by professionals. Furthermore, parents must be informed about the risks in the use of this drug in children. Fil: Lemberg, Abraham. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Fernández, María A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Coll, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Rosello, Diego O.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Romay, Salvador. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Perazzo, Juan C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Filinger, Ester Julia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| Databáze: | OpenAIRE |
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