Advances in the mechanisms of action of cancer-targeting oncolytic viruses
| Autor: | Xiao‑Yuan Zhang, Xin‑Hong Zhu, Gui‑Ling Xiang, Jia‑Xing Sun, Cun‑Zhi Lin, Lu‑Lu Xiu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty business.industry medicine.medical_treatment Cancer Cancer targeting Review medicine.disease Oncolytic virus Clinical trial Radiation therapy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Cancer management medicine In patient Virotherapy business |
| Zdroj: | Oncology letters. 15(4) |
| ISSN: | 1792-1074 |
| Popis: | Cancer virotherapy mediated by oncolytic viruses (OV), has emerged as a novel and effective strategy in cancer therapeutics. Preclinical models have demonstrated anticancer activity against numerous types of cancer. Currently, a number of recombinant viruses are in late phase clinical trials, many of which have demonstrated promising results regarding the safety and reliability of the treatments, particularly when combined with standard antineoplastic therapies. In addition to molecular-targeted therapeutics, genetic engineering of the viruses allows functional complementation to chemotherapy or radiotherapy agents. Co-administration of chemotherapy or radiotherapy is imperative for an effective treatment regime. Additionally, these approaches may be used in combination with current treatments to assist in cancer management. The near future may reveal whether this renewed interest in oncological virotherapy will result in meaningful therapeutic effects in patients. The aim of the present review was to highlight how the knowledge of oncolytic viral specificity and cytotoxicity has advanced in recent years, with a view to discuss OV in clinical application and the future directions of this field. |
| Databáze: | OpenAIRE |
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