Identification of Primary Congenital Hypothyroidism Based on Two Newborn Screens — Utah, 2010–2016
| Autor: | Kim Hart, Robyn Atkinson-Dunn, Stuart K. Shapira, Andreas Rohrwasser, Mary Murray, David E Jones |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pediatrics
medicine.medical_specialty Health (social science) Epidemiology Health Toxicology and Mutagenesis 030209 endocrinology & metabolism Sensitivity and Specificity 03 medical and health sciences Decreased height 0302 clinical medicine Neonatal Screening Health Information Management 030225 pediatrics Utah medicine Congenital Hypothyroidism Humans Primary congenital hypothyroidism Full Report Cognitive impairment Retrospective Studies Newborn screening business.industry Infant Newborn Retrospective cohort study General Medicine medicine.disease Infant newborn Congenital hypothyroidism business |
| Zdroj: | Morbidity and Mortality Weekly Report |
| ISSN: | 1545-861X 0149-2195 |
| Popis: | Newborn screening for primary congenital hypothyroidism is part of the U.S. Recommended Uniform Screening Panel (1,2). Untreated congenital hypothyroidism can result in cognitive impairment and growth complications (decreased height/length). Initial newborn screening for congenital hypothyroidism is typically performed 24-48 hours after birth. Fourteen states, including Utah, perform a routine second screen at approximately 2 weeks of age.* During 2010-2016, a total of 359,432 infants in Utah were screened for congenital hypothyroidism, and 130 cases were diagnosed; among these, 98 had an abnormal first screen, and 25 had an abnormal second screen (seven infants were excluded because of missing data). A retrospective examination of Utah's screening data indicated that 20% of congenital hypothyroidism cases could not have been efficiently identified by a single screen alone. This study highlights the utility of a two-screen process and demonstrates that differential cutoff values for the first and second screens could optimize both screening sensitivity and specificity. |
| Databáze: | OpenAIRE |
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