Stimulation of growth-hormone release with clonidine does not distinguish individual cases of idiopathic Parkinson's disease from those with striatonigral degeneration
| Autor: | M. van't Hof, Fred C.G.J. Sweep, Martin W.I.M. Horstink, J. W. Lenders, Wim J.G. Oyen, Elma Strijks |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Hypertension and Circulation Neurology Parkinson's disease Striatonigral Degeneration Nigrostriatal pathway Pathofysiologie van Hersenen en Gedrag Pathophysiology of Brain and Behaviour Clonidine Statistics Nonparametric Diagnosis Differential Central nervous system disease Hypertensie en circulatie Atrophy Degenerative disease Internal medicine medicine Humans Aged Chemical Endocrinology Analysis of Variance Chi-Square Distribution Development of radiopharmaceuticals for diagnosis and therapy of pathological processes Parkinson Disease Middle Aged medicine.disease Ontwikkeling van radiofarmaca ten behoeve van diagnose en behandeling van ziekteprocessen medicine.anatomical_structure Endocrinology Growth Hormone Neurology (clinical) Psychology medicine.drug |
| Zdroj: | Journal of Neurology, 249, 1206-10 Journal of Neurology, 249, 9, pp. 1206-10 |
| ISSN: | 0340-5354 |
| Popis: | Item does not contain fulltext Multiple System Atrophy (MSA) and idiopathic Parkinson's disease (PD) can be difficult to distinguish. There is an ongoing debate about the diagnostic value of the growth-hormone response to clonidine (CGH-test) in PD and MSA. We investigated whether the CGH-test can identify individual patients in the early stages of PD (n = 21) and Striatonigral Degeneration (SND, n = 11), a particular variety of MSA. Patients were diagnosed on the basis of clinical criteria and IBZM-SPECT. Clonidine induced a greater total serum growth-hormone production in PD than in SND (p = 0.01). However, taking the difference in prevalence of PD and SND into account, and because of the low likelihood ratios of the test, an increase of GH after clonidine increases the pre-test probability for PD by about only 5 %, while an absent response of GH also increases the pre-test probability for SND by about 5 %. We conclude that the CGH-test discriminates between groups of patients with PD and SND, but has little practical diagnostic value for identifying individual patients. |
| Databáze: | OpenAIRE |
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