Association of vitreous vitamin C depletion with diabetic macular ischemia in proliferative diabetic retinopathy

Autor: Yejin Kim, Hyeong Gon Yu, Woon-hyung Ghim, Sanghyeon Oh, Sung Wook Park, Un Chul Park, Jae Seung Kang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
endocrine system diseases
genetic structures
medicine.medical_treatment
Organic chemistry
Vitrectomy
Ascorbic Acid
Vascular Medicine
Biochemistry
Gastroenterology
Antioxidants
chemistry.chemical_compound
Endocrinology
0302 clinical medicine
Ischemia
Medicine and Health Sciences
Vitamin C
Liquid Chromatography
Multidisciplinary
Chromatographic Techniques
Epiretinal Membrane
Vitamins
Diabetic retinopathy
Middle Aged
Oxygen tension
Physical sciences
Chemistry
Retinal Disorders
Medicine
Female
Anatomy
Epiretinal membrane
Research Article
Vitamin
medicine.medical_specialty
Endocrine Disorders
Science
Research and Analysis Methods
Aqueous Humor
Chemical compounds
03 medical and health sciences
Ocular System
Internal medicine
Diabetes mellitus
Organic compounds
Diabetes Mellitus
medicine
Humans
cardiovascular diseases
Retinopathy
Aged
Diabetic Retinopathy
business.industry
Biology and Life Sciences
Cell Biology
medicine.disease
Ascorbic acid
High Performance Liquid Chromatography
eye diseases
Vitreous Body
Ophthalmology
Oxidative Stress
030104 developmental biology
Diabetes Mellitus
Type 2
chemistry
Metabolic Disorders
030221 ophthalmology & optometry
Eyes
sense organs
business
Head
Zdroj: PLoS ONE, Vol 14, Iss 6, p e0218433 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: PurposeVitreous vitamin C, as an anti-oxidant, is responsible for regulating oxygen tension and oxidative stress in the eye. Oxidative stress and retinal ischemia are implicated in the development of proliferative diabetic retinopathy (PDR). In this study, we aimed to determine whether vitreous level of vitamin C is compromised in patients with PDR and to investigate the association of diabetic macular ischemia and vitamin C.MethodsThis prospective study enrolled forty patients who underwent pars plana vitrectomy for the treatment of PDR (PDR group, n = 20) and idiopathic epiretinal membrane (control group, n = 20). Serum, aqueous humor, and the vitreous were collected for the analysis of vitamin C level by HPLC. Diabetic macular ischemia (DMI) in PDR group was evaluated with fluorescein angiography (FA).ResultsPDR patients (60.4 ± 2.1 y) were younger than non-diabetic control patients (67.4 ± 1.2 y). Serum, aqueous, and vitreous levels of vitamin C in PDR were 38.7%, 22.5%, and 11.1% of non-diabetic control group, respectively. All PDR patients had DMI (grade 1: 25%, grade 2: 30%, grade 3: 30%, grade 4: 15%). DMI grade was inversely correlated with the level of vitreous vitamin C (r = -0.546, P = 0.019), not with HbA1C, serum, or aqueous vitamin C level. In addition, the level of vitreous vitamin C (4.5 ± 2.6 μg/ml) in high DMI group (Gr 3 &4) was lower than that (31.0 ± 9.1 μg/ml) in low DMI group (Gr 1&2) (P = 0.015).ConclusionsVitreous level of vitamin C in PDR patients showed a tenfold decrease, which was associated with the degree of macular ischemia. This suggests that vitreous vitamin C depletion may cause macula ischemia in PDR patients.
Databáze: OpenAIRE
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