Kawasaki disease and immunodeficiencies in children: case reports and literature review
| Autor: | Marco Antonio Yamazaki-Nakashimada, Paola Castro-Oteo, Luis Adrian Rosales-Hernandez, Javier Ordoñez-Ortega, Martín Garrido-García, Gabriela López-Herrera, Lorena Aguilar-Zanela, Francisco Rivas-Larrauri, Francisco Otero-Mendoza |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Down syndrome Immunology HIV Infections Disease Mucocutaneous Lymph Node Syndrome Immunocompromised Host 03 medical and health sciences 0302 clinical medicine Immune system Chronic granulomatous disease Rheumatology Adrenal Cortex Hormones Agammaglobulinemia Risk Factors Antineoplastic Combined Chemotherapy Protocols medicine Humans Immunology and Allergy 030212 general & internal medicine Child Immunodeficiency 030203 arthritis & rheumatology Leukemia biology business.industry Immunoglobulins Intravenous Infant Genetic Diseases X-Linked medicine.disease Treatment Outcome Child Preschool biology.protein Kawasaki disease Down Syndrome Antibody business |
| Zdroj: | Rheumatology International. 39:1829-1838 |
| ISSN: | 1437-160X 0172-8172 |
| DOI: | 10.1007/s00296-019-04382-w |
| Popis: | Kawasaki disease (KD) has features that appear supporting an infectious cause with a secondary deranged inflammatory/autoimmune response. The association of KD in adults with human immunodeficiency virus infection and the presence of KD in patients with immunodeficiency disorders support the infectious theory. We present four KD patients associated with immunodeficiencies: one with X-linked agammaglobulinemia, one with HIV infection, and two with leukemia; one of these patients also had Down syndrome. We did a literature search to find out all reported cases of immunodeficiency with KD in children. In immunodeficiency disorders, the inability of the immune system to eradicate the pathogens coupled to an exaggerated inflammatory response, especially in chronic granulomatous disease, may lead to the development of KD. The study of patients with immunodeficiencies complicated with KD may shed light into the etiopathogenesis of the disease. |
| Databáze: | OpenAIRE |
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