The effect of naproxen-sodium on the prostaglandin concentrations of the menstrual blood and uterine 'jet-washings' in dysmenorrehic women
| Autor: | Milan R. Henzl, M.O. Pulkkinen, Arpad I. Csapo |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Prostaglandins F medicine.medical_specialty Adolescent Population Prostaglandin Naproxen Sodium Placebo Biochemistry chemistry.chemical_compound Naproxen Endocrinology Dysmenorrhea Internal medicine medicine Humans Endocrine system Therapeutic Irrigation education Menstrual blood Clinical Trials as Topic education.field_of_study business.industry Prostaglandins E Uterus Prostaglandin synthesis Menstruation chemistry Drug Evaluation Female lipids (amino acids peptides and proteins) business |
| Zdroj: | Prostaglandins. 15:543-550 |
| ISSN: | 0090-6980 |
| Popis: | A group of dysmenorrheic women was treated during two consecutive menstrual bleedings, once with placebo and once with naproxen-sodium (naproxen-Na), a potent inhibitor of prostaglandin synthesis. Concentrations of prostaglandins F and E (PGF, PGE) were assayed in the menstrual blood collected into cervical cups, and in uterine “jet-wash” specimens. In the menstrual blood the high PGF concentrations of patients receiving placebo were significantly reduced following treatment with naproxen-Na (from ± S.E. 227±78.9 ng/ml to 42±19.5 ng/ml; p=0.03). A significant decrease of PGE concentrations was also observed during naproxen-Na treatment (from 10.8±2.1 ng/ml to 3.4±1.7 ng/ml; p=0.03). In the uterine “jet washings” naproxen-Na significantly reduced PGE concentrations (p=0.03) while the decrease of PGF concentrations was close to statistical signficance (p=0.06). These results strenthened the premise of causal relationships between naproxen-Na treatment, decreased uterine prostaglandins, reduction of intrauterine pressure, and relief from dysmenorrehic pain. |
| Databáze: | OpenAIRE |
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