Cardiac electrophysiology: normal and ischemic ionic currents and the ECG
| Autor: | Richard E. Klabunde |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cardiac function curve medicine.medical_specialty Physiology Myocardial Ischemia Ischemia 030204 cardiovascular system & hematology Ion Channels Education Electrocardiography 03 medical and health sciences Heart disorder 0302 clinical medicine Rhythm Heart Conduction System Internal medicine T wave Animals Humans Medicine Ion channel business.industry Cardiac electrophysiology General Medicine medicine.disease Electrophysiology 030104 developmental biology Cardiology business |
| Zdroj: | Advances in Physiology Education. 41:29-37 |
| ISSN: | 1522-1229 1043-4046 |
| DOI: | 10.1152/advan.00105.2016 |
| Popis: | Basic cardiac electrophysiology is foundational to understanding normal cardiac function in terms of rate and rhythm and initiation of cardiac muscle contraction. The primary clinical tool for assessing cardiac electrical events is the electrocardiogram (ECG), which provides global and regional information on rate, rhythm, and electrical conduction as well as changes in electrical activity associated with cardiac disease, particularly ischemic heart disease. This teaching review is written at a level appropriate for first- and second-year medical students. Specific concepts discussed include ion equilibrium potentials, electrochemical forces driving ion movements across membranes, the role of ion channels in determining membrane resting potentials and action potentials, and the conduction of action potentials within the heart. The electrophysiological basis for the ECG is then described, followed by discussion on how ischemia alters cellular electrophysiology and ECG recordings, with particular emphasis on changes in T waves and ST segments of the ECG. |
| Databáze: | OpenAIRE |
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