Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Anti-Inflammatory Drugs and/or with Active Spinal Lesions
| Autor: | Zhao, Yongdong, Wu, Eveline Y, Oliver, Melissa S, Cooper, Ashley M, Basiaga, Matthew L, Vora, Sheetal S, Lee, Tzielan C, Fox, Emily, Amarilyo, Gil, Stern, Sara M, Dvergsten, Jeffrey A, Haines, Kathleen A, Rouster-Stevens, Kelly A, Onel, Karen B, Cherian, Julie, Hausmann, Jonathan S, Miettunen, Paivi, Cellucci, Tania, Nuruzzaman, Farzana, Taneja, Angela, Barron, Karyl S, Hollander, Matthew C, Lapidus, Sivia K, Li, Suzanne C, Ozen, Seza, Girschick, Hermann, Laxer, Ronald M, Dedeoglu, Fatma, Hedrich, Christian M, Ferguson, Polly J, Osteomyeliti, Chronic Nonbacterial, Rheumatolog, Childhood Arthritis |
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| Přispěvatelé: | Çocuk Sağlığı ve Hastalıkları |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Consensus Adolescent Comparative effectiveness research Risk Assessment Severity of Illness Index Article Patient Care Planning 03 medical and health sciences 0302 clinical medicine Refractory Rheumatology Sulfasalazine Internal medicine Severity of illness medicine Humans 030212 general & internal medicine Treatment Failure Child 030203 arthritis & rheumatology Biological Products business.industry Osteomyelitis Chronic recurrent multifocal osteomyelitis Anti-Inflammatory Agents Non-Steroidal medicine.disease Prognosis Surgery Antirheumatic Agents Retreatment Methotrexate Female Spinal Diseases business medicine.drug |
| Zdroj: | ARTHRITIS CARE & RESEARCH |
| Popis: | Objective To develop standardized treatment regimens for chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO) to enable comparative effectiveness treatment studies. Methods Virtual and face-to-face discussions and meetings were held within the CNO subgroup of the Childhood Arthritis and Rheumatology Research Alliance (CARRA). A literature search was conducted, and CARRA membership was surveyed to evaluate available treatment data and identify current treatment practices. Nominal group technique was used to achieve consensus on treatment plans for CNO refractory to non-steroidal anti-inflammatory drug (NSAID) monotherapy and/or with active spinal lesions. Results Three consensus treatment plans (CTPs) were developed for the first 12 months of therapy for CNO patients refractory to NSAID monotherapy and/or with active spinal lesions. The three CTPs are: (1) methotrexate or sulfasalazine, (2) tumor necrosis factor (TNF)-alpha inhibitors with optional use of methotrexate, and (3) bisphosphonates. Short courses of glucocorticoids and continuation of NSAIDs are permitted for all regimens. Consensus was achieved on these CTPs among CARRA members. Consensus was also reached on subject eligibility criteria, initial evaluations that should be conducted prior to the initiation of CTPs, and data items to collect to assess treatment response. Conclusion Three consensus treatment plans were developed for pediatric patients with CNO refractory to NSAIDs and/or with active spinal lesions. Use of these CTPs will provide additional information on efficacy and will generate meaningful data for comparative effectiveness research in CNO. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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