Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: Results from an Italian case-control study
| Autor: | Gian Franco Barabino, Giovanni Lo Scocco, Claudia Gianni, Liliane Chatenoud, Carlo La Vecchia, Enrico Pezzarossa, Paolo Carli, Dennis Linder, Anna Virgili, Luigi Naldi, Pier Luigi Bruni, Roberto Betti, Anna Di Landro, Donatella Schena, Anna Belloni Fortina, Alessandro Farris, Annalisa Barba, Vito Ingordo, Andrea Peserico, C Solaroli, Fabio Arcangeli |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Family history Dermatology Biochemistry Life events Internal medicine Psoriasis medicine Humans Smoking habits Risk factor First-degree relatives Molecular Biology Body mass index business.industry Smoking Case-control study case–control study Cell Biology Middle Aged medicine.disease Surgery Italy Quartile Risk factors Case-Control Studies Relative risk Female business Stress Psychological |
| Popis: | We conducted a case-control study to analyse the association of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events. Cases (n=560; median age 38) were patients with a first diagnosis of psoriasis and a history of skin manifestations of no longer than two years after the reported disease onset. Patients with a new diagnosis of skin diseases other than psoriasis (n=690; median age 36) were selected as controls. The risk of psoriasis was higher in ex- and current smokers than in never-smokers, the relative risk estimates (OR) being 1.9 for ex-smokers and 1.7 for smokers. Smoking was strongly associated with pustular lesions (32 patients, OR=5.3 for smokers). The frequency of psoriasis varied significantly in relation to a family history of psoriasis in first degree relatives, BMI (OR=1.6 and 1.9 for over weighted, BMI 26-29, and obese, BMI/= 30, respectively) and stressful life event score (compared to the lower index quartile, the OR being 2.2 for index values/=115). Risk estimates, when taking into consideration the combined effect of these factors with smoking habits, were consistent with a multiplicative model of risk combination with no significant statistical interaction. |
| Databáze: | OpenAIRE |
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