Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system
| Autor: | Nataša Lekić, Zdeněk Zídek, Kameníková L, Lucie Muchová, Aleš Hořínek, Kateřina Váňová, Hassan Farghali, Dalibor Černý, Eva Kmoníčková |
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| Rok vydání: | 2011 |
| Předmět: |
Lipopolysaccharides
Male Antioxidant Curcumin Lipopolysaccharide Liver cytology medicine.medical_treatment Nitric Oxide Synthase Type II Galactosamine Pharmacology Antioxidants Lipid peroxidation chemistry.chemical_compound Curcuma Drug Discovery medicine Animals Aspartate Aminotransferases Rats Wistar Liver injury Carbon Monoxide Plant Extracts Alanine Transaminase General Medicine medicine.disease Rats Disease Models Animal medicine.anatomical_structure chemistry Biochemistry Liver Hepatocyte Lipid Peroxidation Chemical and Drug Induced Liver Injury Heme Oxygenase-1 Phytotherapy Signal Transduction |
| Zdroj: | Fitoterapia. 82(5) |
| ISSN: | 1873-6971 |
| Popis: | This work studied a relationship between HO-1/CO system and lipid peroxidation with consequent effects on liver functions and NOS-2. We focused on curcumin pretreatment in rat toxic model of d-galactosamine and lipopolysaccharide. Hepatocyte viability, lipid peroxidation, antioxidant status, ALT and AST were evaluated. HO-1 and NOS-2 expressions and respective enzyme activity were determined. Curcumin caused decreases in ALT and AST levels as well as in lipid peroxidation. Furthermore, curcumin pretreatment increased liver HO-1 (2.4-fold, p=0.001), but reduced NOS-2 (4.1-fold, p=0.01) expressions. In conclusion, the tuning of CO/NO pathways is important in shedding light on curcumin's cytoprotective effects in this model. |
| Databáze: | OpenAIRE |
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