An intensified training schedule in recreational male runners is associated with increases in erythropoiesis and inflammation and a net reduction in plasma hepcidin
| Autor: | Arnaud Monnard, Carsten Lundby, Diego Moretti, Michael B. Zimmermann, Gary M. Brittenham, Dorine W. Swinkels, Samuel Mettler, Anneke Geurts-Moetspot, Christophe Zeder |
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| Přispěvatelé: | University of Zurich, Moretti, Diego |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Erythrocyte Indices Male 0301 basic medicine medicine.medical_specialty Erythrocytes Iron Medicine (miscellaneous) 610 Medicine & health 142-005 142-005 Running Hemoglobins 03 medical and health sciences Oxygen Consumption Hepcidins Hepcidin Internal medicine medicine Humans Erythropoiesis Prospective Studies Exercise physiology Exercise Inflammation Nutrition and Dietetics biology Interleukin-6 business.industry 2701 Medicine (miscellaneous) Middle Aged Erythroferrone Iron Isotopes Red blood cell Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] 030104 developmental biology medicine.anatomical_structure Endocrinology Erythropoietin Exercise intensity biology.protein 2916 Nutrition and Dietetics Hemoglobin business medicine.drug |
| Zdroj: | The American Journal of Clinical Nutrition, 108, 1324-1333 The American Journal of Clinical Nutrition, 108, 6, pp. 1324-1333 |
| ISSN: | 0002-9165 |
| Popis: | Background Iron status is a determinant of physical performance, but training may induce both low-grade inflammation and erythropoiesis, exerting opposing influences on hepcidin and iron metabolism. To our knowledge, the combined effects on iron absorption and utilization during training have not been examined directly in humans. Objective We hypothesized that 3 wk of exercise training in recreational male runners would decrease oral iron bioavailability by increasing inflammation and hepcidin concentrations. Design In a prospective intervention, nonanemic, iron-sufficient men (n=10) completed a 34-d study consisting of a 16-d control phase and a 22-d exercise-training phase of 8 km running every second day. We measured oral iron absorption and erythroid iron utilization using oral 57Fe and intravenous 58Fe tracers administered before and during training. We measured hemoglobin mass (mHb) and total red blood cell volume (RCV) by carbon monoxide rebreathing. Iron status, interleukin-6 (IL-6), plasma hepcidin (PHep), erythropoietin (EPO), and erythroferrone were measured before, during, and after training. Results Exercise training induced inflammation, as indicated by an increased mean ± SD IL-6 (0.87 ± 1.1 to 5.17 ± 2.2 pg/mL; P80%) from stores mobilization rather than from increased dietary absorption. Conclusions In iron-sufficient men, mild intensification of exercise intensity increases both inflammation and erythropoiesis. The net effect is to decrease hepcidin concentrations and to tend to increase oral iron absorption. This trial was registered at clinicaltrials.gov as NCT01730521. |
| Databáze: | OpenAIRE |
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