In vitro evaluation of traditionally used Surinamese medicinal plants for their potential anti-leishmanial efficacy
| Autor: | Henk D. F. H. Schallig, I. Magali, E. van den Bogaart, T. Beerens, Gerard J. Schoone, J.A. Hasrat, R.C. Soekhoe, K. Oedairadjsingh, Dennis R. A. Mans |
|---|---|
| Přispěvatelé: | KIT: Biomedical Research, APH - Global Health, Medical Microbiology and Infection Prevention |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
030231 tropical medicine Leishmania donovani Antiprotozoal Agents Solanum promastigote assay 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Surveys and Questionnaires Drug Discovery medicine Bryophyllum pinnatum Quassia amara Humans Medicinal plants Amastigote Leishmaniasis Cell Proliferation Pharmacology anti-leishmanial activity Plants Medicinal Suriname biology Traditional medicine Plant Extracts medicine.disease biology.organism_classification Solanum lycocarpum 030104 developmental biology amastigote-phagocyte assay medicinal plants |
| Zdroj: | Journal of ethnopharmacology, 180, 70-77. Elsevier Ireland Ltd |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2016.01.012 |
| Popis: | Ethnopharmacological relevancePlant-based preparations are extensively used in Surinamese folk medicine for treating leishmaniasis, but often without a scientific rationale.Aim of the studyTo evaluate 25 Surinamese medicinal plants for their potential efficacy against leishmaniasis.Materials and methodsConcentrated plant extracts were evaluated for their effect on the viability of L. (V.) guyanensis AMC, L. (L.) major NADIM5, and L. (L.) donovani GEDII promastigotes, as well as intracellular amastigotes of L. (L.) donovani BHU814 in infected THP-1 cells. Selectivity was assessed by cytotoxicity against THP-1 cells.ResultsThe only plant extract that showed potentially meaningful anti-leishmanial activity was that from Solanum lycocarpum that displayed mean IC50 values of about 51, 61, and 500µg/mL against THP-1 cells. The Bryophyllum pinnatum, Inga alba, and Quassia amara extracts displayed moderate to high IC50 values against promastigotes (about 51 to >500µg/mL) and/or amastigotes (about 224 to >500µg/mL) but were relatively toxic to THP-1 cells (IC50 values |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect