Insulin-Like Growth Factor Binding Protein 1 Predicts Insulin Sensitivity And Insulin Area-Under-The-Curve In Obese, Nondiabetic Adolescents
| Autor: | Phillip D K, Lee, Robert H, Lustig, Carine, Lenders, Jacques, Baillargeon, Darrell M, Wilson, Heidi, Krause-Steinrauf |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male Pediatric Obesity medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Insulin-like growth factor-binding protein 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Internal medicine medicine Humans Insulin 030212 general & internal medicine Glucose tolerance test biology medicine.diagnostic_test business.industry Area under the curve General Medicine Glucose Tolerance Test Prognosis medicine.disease Obesity Metformin Insulin-Like Growth Factor Binding Protein 1 Area Under Curve biology.protein Female Insulin Resistance business Biomarkers hormones hormone substitutes and hormone antagonists Homeostasis medicine.drug |
| Zdroj: | Endocrine Practice. 22:136-142 |
| ISSN: | 1530-891X |
| DOI: | 10.4158/ep15885.or |
| Popis: | Objective: To compare fasting insulin-like growth factor binding protein 1 (IGFBP-1) to other fasting indices as a surrogate marker of insulin sensitivity and resistance calculated from a 3-hour oral glucose tolerance test (oGTT). Methods: Fasting IGFBP-1 and oGTT were performed at 0 (n = 77), 52 (n = 54), and 100 (n = 38) weeks in a study investigating metformin treatment of obesity in adolescents. Insulin area-under-the-curve (IAUC) and the composite insulin sensitivity index (CISI) calculated from the oGTT were compared to fasting IGFBP-1, homeostasis model assessment–insulin resistance, and corrected insulin release at the glucose peak (CIRgp). Results: IGFBP-1 and the ratio of IGFBP-1 to fasting insulin were significantly correlated with indices based on timed sampling, including IAUC, CISI, and CIRgp. In addition, a significant effect of IGFBP-1, but not IGFBP-1 to insulin at time zero, was observed for IAUC and CISI. Conclusion: Our results indicate that fasting IGFBP-1 may be a useful mar... |
| Databáze: | OpenAIRE |
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