Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria

Autor: Hans-Henrik Parving, Peter Gæde, Oluf Pedersen, Bernt Johan von Scholten, Stanley L. Hazen, Zeneng Wang, Tarunveer S. Ahluwalia, Signe Abitz Winther, Peter Rossing, Henrik Reinhard, Jens Ollgaard, Tine W. Hansen
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
B Vitamins
0301 basic medicine
Physiology
Epidemiology
Denmark
Trimethylamine N-oxide
Type 2 diabetes
Cardiovascular Medicine
030204 cardiovascular system & hematology
Biochemistry
Gastroenterology
Cohort Studies
chemistry.chemical_compound
Medical Conditions
0302 clinical medicine
Risk Factors
Medicine and Health Sciences
Metabolites
Risk of mortality
Medicine
Choline
Multidisciplinary
Organic Compounds
Vitamins
Middle Aged
Body Fluids
Chemistry
Blood
Cardiovascular Diseases
Physical Sciences
Female
Kidney Diseases
Metabolic Pathways
Anatomy
medicine.symptom
Research Article
medicine.drug
medicine.medical_specialty
Science
Cardiology
Renal function
Cholines
Blood Plasma
Methylamines
03 medical and health sciences
Internal medicine
Albuminuria
Humans
Carnitine
Mortality
Aged
Creatinine
business.industry
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
Renal System
Cardiovascular Disease Risk
medicine.disease
Metabolism
030104 developmental biology
Diabetes Mellitus
Type 2
chemistry
Medical Risk Factors
business
Biomarkers
Zdroj: PLoS ONE, Vol 16, Iss 3, p e0244402 (2021)
Winther, S A, Øllgaard, J C, Hansen, T W, Von Scholten, B J, Reinhard, H, Ahluwalia, T S, Wang, Z, Gæde, P, Parving, H H, Hazen, S, Pedersen, O & Rossing, P 2021, ' Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria ', PLoS ONE, vol. 16, no. 3, e0244402 . https://doi.org/10.1371/journal.pone.0244402
Winther, S A, Øllgaard, J C, Hansen, T W, Von Scholten, B J, Reinhard, H, Ahluwalia, T S, Wang, Z, Gæde, P, Parving, H H, Hazen, S, Pedersen, O & Rossing, P 2021, ' Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria ', PLOS ONE, vol. 16, no. 3, e0244402 . https://doi.org/10.1371/journal.pone.0244402
PLoS ONE
ISSN: 1932-6203
Popis: Aims The trimethylamine N-oxide (TMAO) pathway is related to intestinal microbiota and has been associated to risk of cardiovascular disease (CVD). We investigated associations between four plasma metabolites in the TMAO pathway and risk of all-cause mortality, CVD and deterioration in renal function in individuals with type 2-diabetes (T2D) and albuminuria. Materials and methods Plasma concentrations of TMAO, choline, carnitine, and betaine were measured by liquid chromatography-tandem mass spectrometry at baseline in 311 individuals with T2D and albuminuria. Information on all-cause mortality and fatal/non-fatal CVD during follow-up was obtained from registries. The association of each metabolite, and a weighted sum score of all four metabolites, with the endpoints were examined. Serum creatinine was measured at follow-up visits and the renal endpoint was defined as eGFR-decline of ≥30%. Associations were analysed using proportional hazards models adjusted for traditional risk factors. Results Baseline mean(SD) age was 57.2(8.2) years and 75% were males. Follow-up was up to 21.9 years (median (IQR) follow-up 6.8 (6.1–15.5) years for mortality and 6.5 (5.5–8.1) years for CVD events). The individual metabolites and the weighted sum score were not associated with all-cause mortality (n = 106) or CVD (n = 116) (adjusted p≥0.09). Higher choline, carnitine and the weighted sum score of the four metabolites were associated with higher risk of decline in eGFR (n = 106) (adjusted p = 0.001, p = 0.03 and p Conclusions In individuals with T2D and albuminuria, higher choline, carnitine and a weighted sum of four metabolites from the TMAO pathway were risk markers for deterioration in renal function during long-term follow-up. Metabolites from the TMAO pathway were not independently related to risk of all-cause mortality or CVD.
Databáze: OpenAIRE
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