Conjunctive representation of what and when in monkey hippocampus and lateral prefrontal cortex during an associative memory task
| Autor: | Nathanael A Cruzado, Earl K. Miller, Marc W. Howard, Zoran Tiganj, Scott L. Brincat |
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| Rok vydání: | 2020 |
| Předmět: |
Computer science
Cognitive Neuroscience Normal Distribution Prefrontal Cortex Stimulus (physiology) Hippocampus 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Memory task Paired associate Memory Animals 0501 psychology and cognitive sciences Prefrontal cortex 030304 developmental biology 0303 health sciences Adaptive memory Working memory 05 social sciences Association Learning Content-addressable memory Macaca mulatta nervous system Lateral prefrontal cortex Neuroscience Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | Hippocampus. 30:1332-1346 |
| ISSN: | 1098-1063 1050-9631 |
| DOI: | 10.1002/hipo.23282 |
| Popis: | Adaptive memory requires the organism to form associations that bridge between events separated in time. Many studies show interactions between hippocampus (HPC) and prefrontal cortex (PFC) during formation of such associations. We analyze neural recording from monkey HPC and PFC during a memory task that requires the monkey to associate stimuli separated by about a second in time. After the first stimulus was presented, large numbers of units in both HPC and PFC fired in sequence. Many units fired only when a particular stimulus was presented at a particular time in the past. These results indicate that both HPC and PFC maintain a temporal record of events that could be used to form associations across time. This temporal record of the past is a key component of the temporal coding hypothesis, a hypothesis in psychology that memory not only encodes what happened, but when it happened. |
| Databáze: | OpenAIRE |
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