Sesquiterpene lactone, a potent drug molecule from Artemisia pallens Wall with anti-inflammatory activity
| Autor: | Anjali D. Ruikar, Supada R. Rojatkar, Ashwini V Misar, Vedavati G Puranik, Ravindra B. Jadhav, Arvind M Mujumdar, N. R. Deshpande |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Models Molecular Magnetic Resonance Spectroscopy Stereochemistry medicine.drug_class Indomethacin Crystallography X-Ray Sesquiterpene lactone Anti-inflammatory Acetone Lactones Mice chemistry.chemical_compound Indometacin Drug Discovery medicine Animals Edema Potency Chromatography High Pressure Liquid chemistry.chemical_classification biology Plant Extracts Anti-Inflammatory Agents Non-Steroidal Hydrogen Bonding Nuclear magnetic resonance spectroscopy Asteraceae biology.organism_classification Artemisia pallens Artemisia chemistry Solvents Tetradecanoylphorbol Acetate Female Sesquiterpenes medicine.drug |
| Zdroj: | Arzneimittelforschung. 61:510-514 |
| ISSN: | 1616-7066 0004-4172 |
| DOI: | 10.1055/s-0031-1296236 |
| Popis: | The present study was carried out to investigate the anti-inflammatory activities of bioactive secondary metabolites of Artemisia pallens Wall, an aromatic herb from family Asteraceae. The results provide evidence for the topical anti-inflammatory properties of Artemisia pallens Wall. The compounds were isolated from the acetone extract of the plant material. The isolates were tested on Swiss albino mice using 12-O-tetradecanoyl phorbol-13-acetate (TPA) induced ear edema. One of the molecules from the extract indicated potent anti-inflammatory activity equivalent to indometacin (CAS 53-86-1). Elucidation of the molecular structures by single crystal x-ray diffraction studies revealed the conformational differences that the six membered rings in both the molecules are at an angle of 28.79 degrees. Presence of hydroxy function for compound 2 may be responsible for higher potency. |
| Databáze: | OpenAIRE |
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