Effects of Telfairia occidentalis (fluted pumpkin; Cucurbitaceae) in mouse models of convulsion, muscle relaxation, and depression
| Autor: | Flora R. Aigbe, Uchenna S Enumah, Mutiu Y. Ajao, Abidemi J. Akindele |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.drug_class medicine.medical_treatment Muscle Relaxation Medicine (miscellaneous) Nigeria Imipramine Mice food Seizures Convulsion medicine Animals Humans Nutrition and Dietetics Traditional medicine business.industry Depression Plant Extracts Muscle relaxant food.food Telfairia occidentalis Cucurbitaceae Disease Models Animal Muscle relaxation Anticonvulsant Neuromuscular Agents Anesthesia Anticonvulsants Female medicine.symptom business Diazepam medicine.drug |
| Zdroj: | Journal of medicinal food. 16(9) |
| ISSN: | 1557-7600 |
| Popis: | Telfairia occidentalis (Cucurbitaceae) is a leafy vegetable used in soup and folk medicine in southern Nigeria. Ethnobotanical survey revealed that preparations of the plant are used in the treatment of central nervous system-related disorders including convulsion. This study was conducted to investigate the effect of the hydroethanolic leaf extract of T. occidentalis in mouse models of convulsion, muscle relaxation, and depression. The strychnine and isoniazid convulsion, traction and climbing muscle relaxation, and forced swim and tail suspension depression tests were used in this study. The extract was administered orally (p.o.) at dose range of 25-800 mg/kg while distilled water (10 mL/kg p.o.) served as negative control. Diazepam (5 mg/kg p.o.) was used as positive control in the convulsion and muscle relaxation models while imipramine (64 mg/kg p.o.) served the same purpose in the depression tests. T. occidentalis significantly increased the onset (P |
| Databáze: | OpenAIRE |
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