Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
| Autor: | Fernando Augusto Rodrigues Mello Junior, Darlen Cardoso de Carvalho, André Salim Khayat, Alayde Vieira Wanderley, Tatiane Piedade de Souza, Amanda de Nazaré Cohen Lima de Castro, João Augusto Nunes de Carvalho Junior Junior, Leandro Magalhães, André Mauricio Ribeiro dos Santos, Marianne Rodrigues Fernandes, Luciana Pereira Colares Leitão, Paulo Pimentel Assumpção, Sidney Santos, Ney Pereira Carneiro dos Santos |
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| Rok vydání: | 2020 |
| Předmět: |
Lymphoblastic Leukemia
Population MTHFD1 lcsh:RC254-282 Pediatrics Article 03 medical and health sciences 0302 clinical medicine Medicine education Gene Genetics education.field_of_study biology Amazon rainforest business.industry Risk effect Hematology CEBPE lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Admixed Oncology Susceptibility 030220 oncology & carcinogenesis Methylenetetrahydrofolate reductase biology.protein ALL Polymorphisms business 030215 immunology |
| Zdroj: | Leukemia Research Reports Leukemia Research Reports, Vol 13, Iss, Pp 100188-(2020) |
| ISSN: | 2213-0489 |
| DOI: | 10.1016/j.lrr.2019.100188 |
| Popis: | Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population. |
| Databáze: | OpenAIRE |
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