Hexokinase domain-containing protein-1 in metabolic diseases and beyond
| Autor: | Brian T. Layden, Carolina M. Pusec, Kristen Lednovich, Md. Wasim Khan, Joseph L. Zapater |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Genome-wide association study Carbohydrate metabolism Biology Article chemistry.chemical_compound Endocrinology Non-alcoholic Fatty Liver Disease Pregnancy Internal medicine Hexokinase medicine Glucose homeostasis Humans Cancer medicine.disease HKDC1 Gestational diabetes Diabetes Gestational Glucose chemistry Female Genome-Wide Association Study |
| Zdroj: | Trends Endocrinol Metab |
| ISSN: | 1879-3061 |
| Popis: | Glucose phosphorylation by hexokinases (HKs) traps glucose in cells and facilitates its usage in metabolic processes dependent on cellular needs. HK domain-containing protein-1 (HKDC1) is a recently discovered protein with wide expression containing HK activity, first noted through a genome-wide association study (GWAS) to be linked with gestational glucose homeostasis during pregnancy. Since then, HKDC1 has been observed to be expressed in many human tissues. Moreover, studies have shown that HKDC1 plays a role in glucose homeostasis by which it may affect the progression of many pathophysiological conditions such as gestational diabetes mellitus (GDM), nonalcoholic steatohepatitis (NASH), and cancer. Here, we review the key studies contributing to our current understanding of the roles of HKDC1 in human pathophysiological conditions and potential therapeutic interventions. |
| Databáze: | OpenAIRE |
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