PD-1 and PD-L1 expression on TILs in peritoneal metastases compared to ovarian tumor tissues and its associations with clinical outcome
| Autor: | Sabine Dekan, Christine Bekos, Stephan Polterauer, Peter Horak, Richard Schwameis, Stefanie Aust, Dietmar Pils, Alexander Reinthaller, Gerda Hofstetter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
CD8 Antigens
medicine.medical_treatment Science Programmed Cell Death 1 Receptor Cancer immunotherapy CD8-Positive T-Lymphocytes Immune control Article B7-H1 Antigen Disease-Free Survival Ovarian tumor Lymphocytes Tumor-Infiltrating Ovarian cancer Programmed cell death 1 Biomarkers Tumor medicine Humans Epithelial ovarian cancer Immune Checkpoint Inhibitors Peritoneal Neoplasms Aged Ovarian Neoplasms Multidisciplinary biology business.industry Immunotherapy Middle Aged Gene Expression Regulation Neoplastic Cancer research biology.protein Biomarker (medicine) Medicine Female Pd l1 expression business CD8 |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The therapeutic potential of immune checkpoint inhibitors is currently being investigated in epithelial ovarian cancer (EOC), but immunological effects of the programmed cell death protein 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) axis in EOC still remain poorly understood. The aim of this study was thus to compare infiltration rates of PD-1 and PD-L1 expressing tumor infiltrating leucocytes (TILs) in primary ovarian tumor tissue and metastatic intraperitoneal implants and to investigate its impact on overall survival (OS). Tumor specimens (ovarian tumor tissues and intraperitoneal metastases) of 111 patients were used to investigate the PD-1, PD-L1 and CD8 expression rates on TILs and PD-L1 expression rate of tumor cells. The percentages of CD8, PD-1, and PD-L1 expressing subpopulations of TILs differ in primary ovarian tumor tissues and metastatic intraperitoneal implants. High PD-1 among TILs in peritoneal metastases were associated with favorable OS. High PD-L1 expression in TILs was associated with poor OS. Combining both factors in peritoneal metastases revealed an unfavorable prognosis. Primary ovarian tumor tissue and intraperitoneal metastatic tissues in EOC might have different strategies to evade immune control. Those findings are of importance for the process of biomarker assessment to predict patients’ response to immunotherapy. |
| Databáze: | OpenAIRE |
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