An Efficient Waste-Free Oxidative Coupling via Regioselective C—H Bond Cleavage: Rh/Cu-Catalyzed Reaction of Benzoic Acids with Alkynes and Acrylates under Air

Autor:	Masahiro Miura, Kenji Ueura, Tetsuya Satoh
Rok vydání:	2007
Předmět:	C h bond Organic Chemistry chemistry.chemical_element Regioselectivity General Medicine Cleavage (embryo) Biochemistry Medicinal chemistry Copper Catalysis Rhodium Isocoumarin chemistry.chemical_compound chemistry Organic chemistry Oxidative coupling of methane Physical and Theoretical Chemistry
Zdroj:	ChemInform. 38
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200733129
Popis:	[structure: see text]. The direct oxidative coupling of benzoic acids with internal alkynes proceeds efficiently in the presence of a rhodium/copper catalyst system under air to afford the corresponding isocoumarin derivatives. The reaction forms no wastes except for water. Under similar conditions, the aerobic coupling with acrylates also takes place smoothly to produce 7-vinylphthalide derivatives via divinylation and subsequent cyclization.
Databáze:	OpenAIRE
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