C-reactive protein and metabolic syndrome in women with previous gestational diabetes
| Autor: | L Volpe, G. Di Cianni, Alessandra Ghio, Ilaria Cuccuru, G. Pellegrini, S. Del Prato, Roberto Miccoli, Luca Benzi, Cristina Lencioni |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Population chemistry.chemical_compound Endocrinology Pregnancy Reference Values Diabetes mellitus Internal medicine Abdomen Internal Medicine medicine Humans Obesity education Homocysteine Abdominal obesity Triglycerides Metabolic Syndrome education.field_of_study medicine.diagnostic_test biology business.industry C-reactive protein Fibrinogen c-reactive protein metabolic syndrome gestational diabetes medicine.disease Gestational diabetes Diabetes Gestational Parity C-Reactive Protein chemistry Hyperglycemia biology.protein Uric acid Female medicine.symptom Metabolic syndrome Lipid profile business Lipoproteins HDL |
| Zdroj: | Diabetes/metabolism research and reviews. 23(2) |
| ISSN: | 1520-7552 |
| Popis: | Background This study evaluates the presence of metabolic syndrome (MS) and its association with C-reactive protein (CRP) and other cardiovascular (CV) risk factors, in a sample of women with and without previous Gestational Diabetes (pGDM). Methods One hundred and sixty-six women with pGDM and 98 women (controls) with uncomplicated pregnancy were studied 16 months after delivery. In all women, plasma glucose, insulin, lipid profile, serum uric acid, C-reactive protein, fibrinogen and homocysteine were measured. MS was defined according to NCEP ATPIII criteria. Results MS was identified in 15 pGDM women (9%) versus 1 control (1%) (p < 0.001). The more frequent metabolic traits were abdominal obesity (36% vs 17%) and low HDL-cholesterol (34% vs 17% in pGDM women and controls, respectively; all p < 0.01). HOMA-R, LDL-cholesterol, fibrinogen, serum uric acid and CRP resulted significantly higher in pGDM women with MS as compared to those without MS after adjustment for BMI. In women with no criteria for MS, only CRP levels were found to be higher in pGDM women compared to controls (p < 0.05). Seventeen percent of pGDM women with no criteria for MS had CRP levels ≥1 mg/L (all controls showed CRP levels |
| Databáze: | OpenAIRE |
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