An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types
| Autor: | Birgit Weber, Joern Groene, Esmeralda Castanos-Velez, Bernd Hinzmann, Eike Staub, Benno Mann, Stefan Roepcke, M. Heinze, Detlev Mennerich, Thomas Brümmendorf, Christian Pilarsky, André Rosenthal, Irina Klaman, Heinz-Johannes Buhr |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Microarray
Colorectal cancer Wiskott-Aldrich Syndrome Protein Neuronal Apoptosis Breast Neoplasms Bioinformatics Proto-Oncogene Proteins c-myc Breast cancer Glioma Cell Line Tumor Neoplasms Drug Discovery medicine Humans Genetics(clinical) Gene Regulatory Networks WIPF1 Expression signature Genetics (clinical) Cell Proliferation Medicine(all) Microarray analysis techniques business.industry Brain Neoplasms Gene Expression Profiling Intracellular Signaling Peptides and Proteins Cancer medicine.disease Prognosis Molecular medicine Gene expression profiling Cytoskeletal Proteins Cancer research Molecular Medicine Original Article Female Tumor Suppressor Protein p53 business Colorectal Neoplasms |
| Zdroj: | Journal of Molecular Medicine (Berlin, Germany) |
| ISSN: | 1432-1440 0946-2716 |
| Popis: | Wiskott–Aldrich syndrome (WAS) predisposes patients to leukemia and lymphoma. WAS is caused by mutations in the protein WASP which impair its interaction with the WIPF1 protein. Here, we aim to identify a module of WIPF1-coexpressed genes and to assess its use as a prognostic signature for colorectal cancer, glioma, and breast cancer patients. Two public colorectal cancer microarray data sets were used for discovery and validation of the WIPF1 co-expression module. Based on expression of the WIPF1 signature, we classified more than 400 additional tumors with microarray data from our own experiments or from publicly available data sets according to their WIPF1 signature expression. This allowed us to separate patient populations for colorectal cancers, breast cancers, and gliomas for which clinical characteristics like survival times and times to relapse were analyzed. Groups of colorectal cancer, breast cancer, and glioma patients with low expression of the WIPF1 co-expression module generally had a favorable prognosis. In addition, the majority of WIPF1 signature genes are individually correlated with disease outcome in different studies. Literature gene network analysis revealed that among WIPF1 co-expressed genes known direct transcriptional targets of c-myc, ESR1 and p53 are enriched. The mean expression profile of WIPF1 signature genes is correlated with the profile of a proliferation signature. The WIPF1 signature is the first microarray-based prognostic expression signature primarily developed for colorectal cancer that is instrumental in other tumor types: low expression of the WIPF1 module is associated with better prognosis. Electronic supplementary material The online version of this article (doi:10.1007/s00109-009-0467-y) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink