How vitamin E and its derivatives regulate tumour cells via the MAPK signalling pathway?'
| Autor: | Wan-Xi Yang, Lan-Min Wang, Zhen-Qi Yu |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
MAPK/ERK pathway
Cell cycle checkpoint MAP Kinase Signaling System p38 mitogen-activated protein kinases Cellular differentiation Apoptosis MAPK cascade Biology medicine.disease_cause p38 Mitogen-Activated Protein Kinases Cell Line Tumor Neoplasms Genetics medicine Humans Vitamin E Cell Proliferation Mitogen-Activated Protein Kinase 3 Cell growth Cell Cycle Cell Differentiation General Medicine Cell biology Carcinogenesis Signal Transduction |
| Zdroj: | Gene. 808:145998 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/j.gene.2021.145998 |
| Popis: | In tumour cells, vitamin E and its derivatives play a critical role in the regulation of multiple signalling pathways through their oxidative and nonoxidative functions. To date, there are 8 known natural vitamin E forms and many kinds of derivatives, among which VES and α-TEA have excellent anticancer activities. The MAPK pathway consists of a complex cascade of proteins that control the proliferation, differentiation and apoptosis of tumour cells. The MAPK pathway includes four subfamilies, ERK1/2, JNK1/2, p38 MAPK, and ERK5. Most of the proteins in these subfamilies interact with each other in a complex manner. The anticancer function of vitamin E and its derivatives is closely related to the MAPK cascade. Studies have shown that in tumour cells, α-T/γ-T/γ-T3/δ-T3/VES/α-TEA regulated ERK1/2, prevent tumorigenesis, inhibit tumour cell growth and metastasis and induce cell differentiation, apoptosis, and cell cycle arrest; γ-T3/δ-T3/VES/α-TEA regulates JNK1/2, induce apoptosis, reduce ceramide synthesis and inhibit proliferation; and γ-T3/δ-T3/VES regulate p38 MAPK and induce apoptosis. This paper reviews the role of vitamin E and its derivatives in the MAPK cascade, and tumour cells are used as a model in an attempt to explore the mechanism of their interactions. |
| Databáze: | OpenAIRE |
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