Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact : analyses from ASSURE-CSU

Autor: Sussman, Gordon, Abuzakouk, Mohamed, Bérard, F., Canonica, W., Oude Elberink, H., Giménez Arnau, Ana M., Grattan, C., Hollis, K., Hunter, S., Knulst, A., Lacour, J.-P., Lynde, C., Marsland, A., McBride, D., Maurer, Marcus., Nakonechna, A., Ortiz de Frutos, J., Reynolds, M., Sweeney, C., Tian, H., Weller, Karsten., Wolin, D., Balp, Maria Magdalena., Universitat Autònoma de Barcelona
Přispěvatelé: Groningen Research Institute for Asthma and COPD (GRIAC)
Rok vydání: 2018
Předmět:
Male
Internationality
Urticaria
Omalizumab
Economic burden
DISEASE-ACTIVITY
Severity of Illness Index
Skin and Eye Diseases
030207 dermatology & venereal diseases
urticaria
0302 clinical medicine
Quality of life
QUALITY-OF-LIFE
immune system diseases
Observational study
Activities of Daily Living
Immunology and Allergy
skin and connective tissue diseases
Aged
80 and over
Medical record
food and beverages
Dermatology Life Quality Index
Middle Aged
DAILY DIARY
Qualitat de vida
economic burden
Regression Analysis
Population study
Original Article
Female
medicine.symptom
BURDEN
Urticària
medicine.drug
Adult
medicine.medical_specialty
Immunology
QUESTIONNAIRE
VALIDATION
Young Adult
03 medical and health sciences
OMALIZUMAB
Internal medicine
Post-hoc analysis
medicine
Humans
cardiovascular diseases
Angioedema
Aged
Retrospective Studies
Physician-Patient Relations
business.industry
angioedema
Patient Acceptance of Health Care
Health Surveys
030228 respiratory system
quality of life
Chronic Disease
observational study
ORIGINAL ARTICLES
business
CHRONIC IDIOPATHIC URTICARIA
REAL-WORLD
Zdroj: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Sussman, G, Abuzakouk, M, Bérard, F, Canonica, W, Oude Elberink, H, Giménez-arnau, A, Grattan, C, Hollis, K, Hunter, S, Knulst, A, Lacour, J, Lynde, C, Marsland, A, Mcbride, D, Maurer, M, Nakonechna, A, Ortiz De Frutos, J, Reynolds, M, Sweeney, C, Tian, H, Weller, K, Wolin, D & Balp, M 2018, ' Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact: Analyses from ASSURE-CSU ', Allergy, vol. 73, no. 8, pp. 1724-1734 . https://doi.org/10.1111/all.2018.73.issue-8
Allergy, 73(8), 1724-1734. Wiley-Blackwell
Allergy, 73(8), 1724. Wiley-Blackwell
Allergy
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Recercat. Dipósit de la Recerca de Catalunya
instname
ISSN: 0105-4538
DOI: 10.1111/all.2018.73.issue-8
Popis: Background ASSURE‐CSU revealed differences in physician and patient reporting of angioedema. This post hoc analysis was conducted to evaluate the actual rate of angioedema in the study population and explore differences between patients with and without angioedema. Methods This international observational study assessed 673 patients with inadequately controlled chronic spontaneous urticaria (CSU). Physicians abstracted angioedema data from medical records, which were compared with patient‐reported data. Patients in the Yes‐angioedema category had angioedema reported in the medical record and a patient‐reported source. For those in the No‐angioedema category, angioedema was reported in neither the medical record nor a patient‐reported source. Those in the Misaligned category had angioedema reported in only one source. Statistical comparisons between Yes‐angioedema and No‐angioedema categories were conducted for measures of CSU activity, health‐related quality of life (HRQoL), productivity and healthcare resource utilization (HCRU). Regression analyses explored the relationship between Dermatology Life Quality Index (DLQI) score and angioedema, adjusting for important covariates. Results Among evaluable patients, 259 (40.3%), 173 (26.9%) and 211 (32.8%) were in the Yes‐angioedema, No‐angioedema and Misaligned category, respectively. CSU activity and impact on HRQoL, productivity, and HCRU was greater for Yes‐angioedema patients than No‐angioedema patients. After covariate adjustment, mean DLQI score was significantly higher (indicating worse HRQoL) for patients with angioedema versus no angioedema (9.88 vs 7.27, P
Databáze: OpenAIRE
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