Exposure to soil contaminated with an environmental PCB/PCDD/PCDF mixture modulates ultraviolet radiation-induced non-melanoma skin carcinogenesis in the Crl:SKH1–hrBR hairless mouse
Autor: | David J. Schaeffer, Larry G. Hansen, Carla M.K. Morrow, Jim Hartman, Rhian B. Cope, Kanjana Imsilp |
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Rok vydání: | 2003 |
Předmět: |
Cancer Research
Neoplasms Radiation-Induced Polychlorinated Dibenzodioxins Skin Neoplasms Ultraviolet Rays medicine.disease_cause Mice chemistry.chemical_compound medicine Animals Soil Pollutants Irradiation Carcinogen Benzofurans Skin Mice Hairless Papilloma integumentary system Methanol Polychlorinated biphenyl Dibenzofurans Polychlorinated Contamination Polychlorinated Biphenyls Molecular biology Hairless Oncology chemistry Carcinoma Squamous Cell Environmental Pollutants Female Carcinogenesis Polychlorinated dibenzofurans Epidermal thickening |
Zdroj: | Cancer Letters. 191:145-154 |
ISSN: | 0304-3835 |
DOI: | 10.1016/s0304-3835(02)00636-5 |
Popis: | Chlorinated aromatic contaminants are active in carcinogenic processes within the skin and may have the potential to modulate ultraviolet radiation (UV)-induced skin carcinogenesis. Exposure to a complex environmental PCB/PCDD/PCDF mixture (polychlorinated biphenyls/polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans) during the irradiation phase of photocarcinogenesis was associated with significant (P < or = 0.001) reductions in papilloma incidence and squamous cell carcinoma multiplicity at irradiated skin sites. This protective effect was associated with significantly (P < 0.0001) reduced chronic epidermal thickening in UV and contaminant-exposed mice compared with mice exposed to UV only. Contaminant exposure was also associated with increased UV absorbance of skin methanol extracts implying a sunscreen-like effect. |
Databáze: | OpenAIRE |
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