Exposure to soil contaminated with an environmental PCB/PCDD/PCDF mixture modulates ultraviolet radiation-induced non-melanoma skin carcinogenesis in the Crl:SKH1–hrBR hairless mouse

Autor: David J. Schaeffer, Larry G. Hansen, Carla M.K. Morrow, Jim Hartman, Rhian B. Cope, Kanjana Imsilp
Rok vydání: 2003
Předmět:
Zdroj: Cancer Letters. 191:145-154
ISSN: 0304-3835
DOI: 10.1016/s0304-3835(02)00636-5
Popis: Chlorinated aromatic contaminants are active in carcinogenic processes within the skin and may have the potential to modulate ultraviolet radiation (UV)-induced skin carcinogenesis. Exposure to a complex environmental PCB/PCDD/PCDF mixture (polychlorinated biphenyls/polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans) during the irradiation phase of photocarcinogenesis was associated with significant (P < or = 0.001) reductions in papilloma incidence and squamous cell carcinoma multiplicity at irradiated skin sites. This protective effect was associated with significantly (P < 0.0001) reduced chronic epidermal thickening in UV and contaminant-exposed mice compared with mice exposed to UV only. Contaminant exposure was also associated with increased UV absorbance of skin methanol extracts implying a sunscreen-like effect.
Databáze: OpenAIRE