Serotype distribution and antimicrobial resistance of invasive Streptococcus pneumoniae isolates among Croatian adults during a fifteenyear period (2005-2019)
| Autor: | Iva Butić, Marija Gužvinec, Marko Jelić, Irena Groš, Sandra Lucić, Mile Bošnjak, Arjana Tambić Andrašević |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Croatian Medical Journal Volume 63 Issue 2 |
| ISSN: | 1332-8166 0353-9504 |
| Popis: | Aim To assess serotype distribution, antibiotic resistance, and vaccine coverage against Streptococcus pneumoniae causing invasive infections in Croatian adults from 2005 to 2019. Methods In this retrospective study, invasive pneumococ - cal strains were collected through a microbiological lab - oratory network with country coverage >95%. Capsular typing was performed with the Quellung reaction. In vitro susceptibility testing was carried out according to the Eu - ropean Committee on Antimicrobial Susceptibility Twating guidelines. In macrolide-resistant isolates, the presence of ermB and mefA genes was evaluated. Results During the fifteen-year study period, 1123 inva - sive pneumococcal isolates were obtained. The most prev - alent serotypes were 3, 14, 19A, 9V, 7F, and 23F, comprising 60% of all invasive pneumococcal isolates. Serotype 3 was the dominant serotype, with the highest prevalence in pa - tients ≥65 years of age. Penicillin susceptibility, increased exposure was 18.6%, mostly associated with serotypes 14 and 19A. Resistance to penicillin was low ( |
| Databáze: | OpenAIRE |
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