Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5)

Autor:	Tor Svensson, Alecia Peterson, Krister Österlund, David Karis, Udo Bauer, Lance G. Hammerland, Karolina Nilsson, David Wensbo, Maria Boije, Peter Bach, Andreas Wållberg
Rok vydání:	2006
Předmět:	Stereochemistry Pyridines Receptor Metabotropic Glutamate 5 Clinical Biochemistry Pharmaceutical Science Receptors Metabotropic Glutamate Biochemistry Structure-Activity Relationship APICA Drug Discovery Structure–activity relationship Animals Molecular Biology Molecular Structure Metabotropic glutamate receptor 5 Chemistry Organic Chemistry Glutamate receptor Rats Metabotropic receptor Cross-Linking Reagents Liver Alkynes Molecular Medicine Metabotropic glutamate receptor 1 Metabotropic glutamate receptor 2 Linker
Zdroj:	Bioorganicmedicinal chemistry letters. 16(18)
ISSN:	0960-894X
Popis:	Studies of structure-activity relationships for the linker in a new series of metabotropic glutamate receptor 5 antagonists are presented together with in vitro and in vivo pharmacokinetic data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a169826f562c4c45c7621b7f2fd63d https://pubmed.ncbi.nlm.nih.gov/16837196 Zobrazit plný text záznamu Full Text from ScienceDirect