Juvenile pilocytic astrocytomas do not undergo spontaneous malignant transformation: grounds for designation as hamartomas
| Autor: | Soudabeh Givrad, Cameron F. Parsa |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Neoplasms Radiation-Induced Adolescent Optic glioma Hamartoma Astrocytoma Malignant transformation Cellular and Molecular Neuroscience Glioma medicine Humans Child neoplasms Anaplasia Brain Diseases Pilocytic astrocytoma business.industry Brain Neoplasms Juvenile Pilocytic Astrocytoma Neoplasms Second Primary Middle Aged medicine.disease Sensory Systems nervous system diseases Ophthalmology Cell Transformation Neoplastic nervous system Child Preschool Disease Progression medicine.symptom business |
| Zdroj: | The British journal of ophthalmology. 92(1) |
| ISSN: | 1468-2079 |
| Popis: | Aim: To determine whether juvenile pilocytic astrocytomas WHO grade I have the potential for spontaneous malignant transformation. Methods: A literature search was performed, crossreferencing juvenile pilocytic astrocytoma, pilocytic astrocytoma, astrocytoma grade I, optic glioma, glioma, low-grade gliomas, polar spongioblastoma, gliocytoma embryonale, and malignant transformation, anaplasia or anaplastic change. Bibliographic PubMed and Google searches were performed, and reference ophthalmology and neuropathology textbooks were utilised. Results: A total of 52 purported cases of malignant transformation were found. Twenty-two of these tumours, however, did not initially match criteria for juvenile pilocytic astrocytoma WHO grade I and were excluded. Six other cases were located within the irradiated field but represented anaplasias developing independently of the primary tumour. The remaining 24 malignancies had all been previously irradiated. Conclusion: Juvenile pilocytic astrocytomas WHO grade I do not undergo spontaneous anaplastic transformation. Malignant transformations have only been demonstrated following radiation therapy. Earlier clinical and histopathological opinions regarding juvenile pilocytic astrocytomas as hamartomatous lesions are reaffirmed. Despite the generally acknowledged low-growth potential of juvenile pilocytic astrocytomas, sometimes compared with hamartomatous lesions, 1–3 |
| Databáze: | OpenAIRE |
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