Interruption of Antiretroviral Therapy Initiated during Primary HIV-1 Infection: Impact of a Therapeutic Vaccination Strategy Combined with Interleukin (IL)-2 Compared with IL-2 Alone in the ANRS 095 Randomized Study
| Autor: | Maria Beumont-Mauviel, Cécile Goujard, Raphaelle El Habib, Jean-Pierre Aboulker, Vincent Meiffrédy, Jean-François Delfraissy, Houria Hendel-Chavez, Alain Venet, Yves Levy, Yacine Taoufik, Christine Rouzioux, Marianne Burgard, Fabienne Marcellin |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Interleukin 2 Anti-HIV Agents T cell Immunology HIV Infections CD8-Positive T-Lymphocytes Lymphocyte Activation Drug Administration Schedule Immune system Acquired immunodeficiency syndrome (AIDS) Virology Immunopathology Humans Medicine Cell Proliferation AIDS Vaccines biology business.industry Vaccination virus diseases Interleukin Middle Aged medicine.disease biology.organism_classification Treatment Outcome Infectious Diseases medicine.anatomical_structure Lentivirus HIV-1 Interleukin-2 Female business medicine.drug |
| Zdroj: | AIDS Research and Human Retroviruses. 23:1105-1113 |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | HIV-specific T cell responses play a critical role in the control of infection. We evaluated the impact of immune-based interventions in patients first treated during primary HIV-1 infection (PHI). Forty-three patients were randomized within three groups, to receive either interleukin-2 (IL-2 group), or boosts of ALVAC-HIV (vCP1433) and LIPO-6T followed by interleukin-2 (Vac-IL2 group), compared with no immune intervention (control group), and were monitored for T cell responses. Impact of strategies on viral replication was subsequently assessed during long-term treatment interruption. HIV-specific CD4(+) T cell responses did not change during the study period in immunized patients relative to controls, and vaccination had only a transient effect on interferon-gamma-producing CD8 responses. Viral rebound after treatment interruption was similar in immunized patients and controls. Forty percent of patients had HIV RNA values10,000 copies/ml 12 weeks after interruption. The cumulative time off treatment represented almost half the total follow-up period. Immunological and virological status during PHI and HIV DNA load at interruption were predictive of the level of viral rebound after treatment interruption, whereas HIV RNA level during PHI and HIV DNA level at interruption were predictive of the time off treatment. Treatment interruption is safe in patients treated early after primary HIV infection. On the basis of this pilot study, HIV immunizations and interleukin-2 appear to have no supplementary benefit. |
| Databáze: | OpenAIRE |
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