Contractile Responses in Spontaneously Hypertensive Rats after Transient Middle Cerebral Artery Occlusion
| Autor: | Maryam Mostajeran, Lars Edvinsson, Anne Sofie Grell, Saema Ansar |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Middle Cerebral Artery Neurology Cerebral arteries Blood Pressure Viper Venoms 030204 cardiovascular system & hematology Rats Inbred WKY 03 medical and health sciences 0302 clinical medicine Internal medicine Rats Inbred SHR Medicine Animals Receptor Stroke Pharmacology Endothelin-1 business.industry Angiotensin II Infarction Middle Cerebral Artery General Medicine medicine.disease Endothelin 1 Vasodilation Dilator Hypertension Cardiology Potassium Carbachol medicine.symptom business 030217 neurology & neurosurgery Vasoconstriction |
| Zdroj: | Pharmacology. 101(3-4) |
| ISSN: | 1423-0313 |
| Popis: | Stroke is one of the leading causes of mortality and morbidity worldwide, and few therapeutic treatments have shown beneficial effect clinically. One reason for this could be the lack of risk factors incorporated into the preclinical stroke research. We have previously demonstrated phenotypic receptor changes to be one of the injurious mechanisms occurring after stroke but mostly in healthy rats. The aim of this study was to investigate if hypertension has an effect on vasoconstrictive receptor responses to endothelin 1, sarafotoxin 6c and angiotensin II after stroke by inducing transient middle cerebral artery occlusion in spontaneously hypertensive rats and Wistar-Kyoto rats using the wire-myograph. We demonstrated an increased contractile response to endothelin 1 and extracellular potassium as well as an increased carbachol-induced dilator response in the middle cerebral arteries from hypertensive rats after stroke. This study demonstrates the importance of including risk factors in experimental stroke research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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