Impact of Pupil Dilation on Optical Coherence Tomography Angiography Retinal Microvasculature in Healthy Eyes
| Autor: | Robert N. Weinreb, James A. Proudfoot, George Villatoro, Christopher Bowd, Rafaella C. Penteado, Andrew J Li, Khoa Dinh Nguyen, Sasan Moghimi, Linda M. Zangwill, Elham Ghahari, Huiyuan Hou, Patricia Isabel C. Manalastas |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Mydriatics Intraocular pressure genetic structures Glaucoma Administration Ophthalmic ganglion cell complex thickness Neurodegenerative Eye optical coherence tomography angiography Ophthalmology & Optometry Ophthalmic Phenylephrine Tropicamide chemistry.chemical_compound 0302 clinical medicine Pupillary response Fluorescein Angiography Tomography medicine.diagnostic_test Middle Aged Fluorescein angiography Healthy Volunteers Drug Combinations Administration Optic nerve Biomedical Imaging Female dilation Tomography Optical Coherence medicine.drug Adult medicine.medical_specialty Clinical Sciences Article Young Adult 03 medical and health sciences Clinical Research vessel density Ophthalmology medicine Humans Eye Disease and Disorders of Vision Intraocular Pressure Aged optical coherence tomography business.industry Neurosciences Retinal Vessels Pupil Retinal medicine.disease eye diseases Confidence interval Capillaries chemistry Optical Coherence Microvessels 030221 ophthalmology & optometry sense organs Ophthalmic Solutions business 030217 neurology & neurosurgery |
| Zdroj: | Journal of glaucoma, vol 29, iss 11 J Glaucoma |
| ISSN: | 1057-0829 |
| DOI: | 10.1097/ijg.0000000000001647 |
| Popis: | PReCIS:: Small but significant decreases in optical coherence tomography angiography (OCTA)-measured circumpapillary capillary density (cpCD) were observed in healthy eyes dilated with 2.5% phenylephrine/0.5% tropicamide. Although likely clinically insignificant, ophthalmologists should consider these changes when interpreting OCTA results from dilated eyes. Purpose The purpose of this study was to investigate the effect of pupil dilation using 2.5% phenylephrine and 0.5% tropicamide on quantitative assessment of retinal microvasculature using OCTA. Methods OptoVue AngioVue high density (HD) and non-HD OCTA macula and optic nerve head (ONH) images were obtained at 15-minute intervals predilation and postdilation in 26 healthy participants (mean age: 40.0; 95% confidence interval=33.9, 46.1 y). Superficial macular vessel density (VD) was measured in the whole image VD and the parafoveal region VD. ONH capillary density was measured in the whole image capillary density and the cpCD region. Differences between predilation and postdilation densities were assessed using linear mixed effects models to account for within-patient correlation. Results Instillation of dilating drops resulted in a small but statistically significant reduction in non-HD ONH whole image capillary density of 0.6%, from a mean of 45.2% (95% confidence interval=41.9%, 48.4%) to 44.6% (41.4%, 47.8%) (P=0.046). A similar reduction in non-HD ONH cpCD of 0.8% also was observed, from a mean of 49.3% (45.3%, 53.3%) to 48.5% (44.5%, 52.4%) (P=0.025). No postdilation decreases in macular VD or HD ONH capillary density were observed. Conclusions Pupil dilation using topical 2.5% phenylephrine and 0.5% tropicamide results in a small but statistically significant reduction in non-HD ONH whole image and cpCD in healthy eyes. The observed reduction likely is not clinically significant because the observed reduction was within the previously reported range of measurement variability. Further studies should consider investigating these effects in nonhealthy eyes with glaucoma and media opacities, as well as older individuals. |
| Databáze: | OpenAIRE |
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