An Adenosine Receptor for Olfaction in Fish
| Autor: | Miwa Masuda, Tetsuya Koide, Yoshihiro Yoshihara, Towako Hiraki-Kajiyama, Nobuhiko Miyasaka, Noriko Wakisaka |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adenosine Population Sensory system Olfaction Nose Biology Olfactory Receptor Neurons General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Adenosine Triphosphate Olfactory Mucosa medicine Animals education Phylogeny Zebrafish Adenosine Triphosphatases Glomerulus (olfaction) education.field_of_study Behavior Animal Receptors Purinergic P1 Adenosine receptor Olfactory bulb Smell 030104 developmental biology medicine.anatomical_structure Biochemistry Calcium General Agricultural and Biological Sciences Olfactory epithelium medicine.drug |
| Zdroj: | Current Biology. 27:1437-1447.e4 |
| ISSN: | 0960-9822 |
| DOI: | 10.1016/j.cub.2017.04.014 |
| Popis: | Nucleotides released from food sources into environmental water are supposed to act as feeding cues for many fish species. However, it remains unknown how fish can sensitively detect those nucleotides. Here we discover a novel olfactory mechanism for ATP sensing in zebrafish. Upon entering into the nostril, ATP is efficiently converted into adenosine through enzymatic reactions of two ecto-nucleotidases expressed in the olfactory epithelium. Adenosine subsequently activates a small population of olfactory sensory neurons expressing a novel adenosine receptor A2c that is unique to fishes and amphibians. The information is then transmitted to a single glomerulus in the olfactory bulb and further to four regions in higher olfactory centers. These results provide conclusive evidence for a sophisticated enzyme-linked receptor mechanism underlying detection of ATP as a food-derived attractive odorant linking to foraging behavior that is crucial and common to aquatic lower vertebrates. |
| Databáze: | OpenAIRE |
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